Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study
CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Paulista de Medicina
|
| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000400007&lng=en&tlng=en |
| _version_ | 1818540974182236160 |
|---|---|
| author | Patrícia Magda Soares César Cabello Luis Alberto Magna Eduardo Tinois Cristina Laguna Benetti-Pinto |
| author_facet | Patrícia Magda Soares César Cabello Luis Alberto Magna Eduardo Tinois Cristina Laguna Benetti-Pinto |
| author_sort | Patrícia Magda Soares |
| collection | DOAJ |
| description | CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF. |
| first_indexed | 2024-12-11T22:02:27Z |
| format | Article |
| id | doaj.art-9f93ab87e2af4c7bb1c1f9616a57a940 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-11T22:02:27Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-9f93ab87e2af4c7bb1c1f9616a57a9402022-12-22T00:49:04ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460128421121410.1590/S1516-31802010000400007S1516-31802010000400007Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional studyPatrícia Magda Soares0César Cabello1Luis Alberto Magna2Eduardo Tinois3Cristina Laguna Benetti-Pinto4Universidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual PaulistaCONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000400007&lng=en&tlng=enHormone replacement therapyMammographyMenopausePremature ovarian failureBreast |
| spellingShingle | Patrícia Magda Soares César Cabello Luis Alberto Magna Eduardo Tinois Cristina Laguna Benetti-Pinto Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study São Paulo Medical Journal Hormone replacement therapy Mammography Menopause Premature ovarian failure Breast |
| title | Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study |
| title_full | Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study |
| title_fullStr | Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study |
| title_full_unstemmed | Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study |
| title_short | Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study |
| title_sort | breast density in women with premature ovarian failure or postmenopausal women using hormone therapy analytical cross sectional study |
| topic | Hormone replacement therapy Mammography Menopause Premature ovarian failure Breast |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000400007&lng=en&tlng=en |
| work_keys_str_mv | AT patriciamagdasoares breastdensityinwomenwithprematureovarianfailureorpostmenopausalwomenusinghormonetherapyanalyticalcrosssectionalstudy AT cesarcabello breastdensityinwomenwithprematureovarianfailureorpostmenopausalwomenusinghormonetherapyanalyticalcrosssectionalstudy AT luisalbertomagna breastdensityinwomenwithprematureovarianfailureorpostmenopausalwomenusinghormonetherapyanalyticalcrosssectionalstudy AT eduardotinois breastdensityinwomenwithprematureovarianfailureorpostmenopausalwomenusinghormonetherapyanalyticalcrosssectionalstudy AT cristinalagunabenettipinto breastdensityinwomenwithprematureovarianfailureorpostmenopausalwomenusinghormonetherapyanalyticalcrosssectionalstudy |