Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide
Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/7/1365 |
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| author | Shi Guo Zhengmei Song Ding-Kun Ji Giacomo Reina Jean-Daniel Fauny Yuta Nishina Cécilia Ménard-Moyon Alberto Bianco |
| author_facet | Shi Guo Zhengmei Song Ding-Kun Ji Giacomo Reina Jean-Daniel Fauny Yuta Nishina Cécilia Ménard-Moyon Alberto Bianco |
| author_sort | Shi Guo |
| collection | DOAJ |
| description | Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological environments. Therefore, preparing covalently functionalized GO using straightforward and versatile methods is highly valuable. Phototherapies, including photothermal therapy (PTT) and photodynamic therapy (PDT), have shown great potential as effective therapeutic approaches against cancer. To overcome the limits of a single method, the combination of PTT and PDT can lead to a combined effect with a higher therapeutic efficiency. In this work, we prepare a folic acid (FA) and chlorin e6 (Ce6) double-functionalized GO for combined targeted PTT/PDT. This conjugate can penetrate rapidly into cancer cells and macrophages. A combined effect of PTT and PDT is observed, leading to a higher killing efficiency toward different types of cells involved in cancer and other diseases. Our work provides a simple protocol to prepare multifunctional platforms for the treatment of various diseases. |
| first_indexed | 2024-03-09T13:11:49Z |
| format | Article |
| id | doaj.art-9f9665cfdf65429f930b74a434838f0a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T13:11:49Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9f9665cfdf65429f930b74a434838f0a2023-11-30T21:41:22ZengMDPI AGPharmaceutics1999-49232022-06-01147136510.3390/pharmaceutics14071365Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene OxideShi Guo0Zhengmei Song1Ding-Kun Ji2Giacomo Reina3Jean-Daniel Fauny4Yuta Nishina5Cécilia Ménard-Moyon6Alberto Bianco7CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceCNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceCNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceCNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceCNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceGraduate School of Natural Science and Technology, Okayama University, Tsushimanaka, Kita-ku, Okayama 700-8530, JapanCNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceCNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, FranceGraphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological environments. Therefore, preparing covalently functionalized GO using straightforward and versatile methods is highly valuable. Phototherapies, including photothermal therapy (PTT) and photodynamic therapy (PDT), have shown great potential as effective therapeutic approaches against cancer. To overcome the limits of a single method, the combination of PTT and PDT can lead to a combined effect with a higher therapeutic efficiency. In this work, we prepare a folic acid (FA) and chlorin e6 (Ce6) double-functionalized GO for combined targeted PTT/PDT. This conjugate can penetrate rapidly into cancer cells and macrophages. A combined effect of PTT and PDT is observed, leading to a higher killing efficiency toward different types of cells involved in cancer and other diseases. Our work provides a simple protocol to prepare multifunctional platforms for the treatment of various diseases.https://www.mdpi.com/1999-4923/14/7/1365Carbon nanomaterialsphototherapytargetingchlorin e6macrophages |
| spellingShingle | Shi Guo Zhengmei Song Ding-Kun Ji Giacomo Reina Jean-Daniel Fauny Yuta Nishina Cécilia Ménard-Moyon Alberto Bianco Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide Pharmaceutics Carbon nanomaterials phototherapy targeting chlorin e6 macrophages |
| title | Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide |
| title_full | Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide |
| title_fullStr | Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide |
| title_full_unstemmed | Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide |
| title_short | Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide |
| title_sort | combined photothermal and photodynamic therapy for cancer treatment using a multifunctional graphene oxide |
| topic | Carbon nanomaterials phototherapy targeting chlorin e6 macrophages |
| url | https://www.mdpi.com/1999-4923/14/7/1365 |
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