Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict
This paper represents itself comment on the work “Soler-Polo, D., Mendieta-Moreno, J.I., Trabada, D.G., Mendieta, J., Ortega, J. Proton Transfer in Guanine-Cytosine Base Pairs in B-DNA. J. Chem. Theory Comput. 2019, 15, 12, 6984-6991”. In this Comment it was outlined thoughts according the possibili...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2020-08-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2020/09/Brovarets_4_20.pdf |
| _version_ | 1797427805376479232 |
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| author | O. O. Brovarets’ D. M. Hovorun |
| author_facet | O. O. Brovarets’ D. M. Hovorun |
| author_sort | O. O. Brovarets’ |
| collection | DOAJ |
| description | This paper represents itself comment on the work “Soler-Polo, D., Mendieta-Moreno, J.I., Trabada, D.G., Mendieta, J., Ortega, J. Proton Transfer in Guanine-Cytosine Base Pairs in B-DNA. J. Chem. Theory Comput. 2019, 15, 12, 6984-6991”. In this Comment it was outlined thoughts according the possibility for the Watson-Crick G⸱C DNA base pair to tautomerise by the Löwdin’s mechanism and so to cause spontaneous point mutations. Based on the comprehensive analysis, authors arrive to the conclusion that mechanism, which has been analyzed in work (J. Chem. Theory Comput. 2019, 15, 12, 6984-6991) is not possible. |
| first_indexed | 2024-03-09T08:50:09Z |
| format | Article |
| id | doaj.art-9f970fceed2d444eb3099d6745c99d4c |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:50:09Z |
| publishDate | 2020-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-9f970fceed2d444eb3099d6745c99d4c2023-12-02T14:35:58ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032020-08-0192412412610.15407/ubj92.04.124Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdictO. O. Brovarets’0D. M. Hovorun1https://orcid.org/0000-0002-5579-5520Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, KyivInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, KyivThis paper represents itself comment on the work “Soler-Polo, D., Mendieta-Moreno, J.I., Trabada, D.G., Mendieta, J., Ortega, J. Proton Transfer in Guanine-Cytosine Base Pairs in B-DNA. J. Chem. Theory Comput. 2019, 15, 12, 6984-6991”. In this Comment it was outlined thoughts according the possibility for the Watson-Crick G⸱C DNA base pair to tautomerise by the Löwdin’s mechanism and so to cause spontaneous point mutations. Based on the comprehensive analysis, authors arrive to the conclusion that mechanism, which has been analyzed in work (J. Chem. Theory Comput. 2019, 15, 12, 6984-6991) is not possible.http://ukrbiochemjournal.org/wp-content/uploads/2020/09/Brovarets_4_20.pdfspontaneous point mutations in dnaproton transferwatson-crick g⸱c dna base pairlöwdin’s mechanism |
| spellingShingle | O. O. Brovarets’ D. M. Hovorun Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict The Ukrainian Biochemical Journal spontaneous point mutations in dna proton transfer watson-crick g⸱c dna base pair löwdin’s mechanism |
| title | Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict |
| title_full | Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict |
| title_fullStr | Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict |
| title_full_unstemmed | Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict |
| title_short | Tautomeric hypothesis: to be or not to be? Quantum-mechanical verdict |
| title_sort | tautomeric hypothesis to be or not to be quantum mechanical verdict |
| topic | spontaneous point mutations in dna proton transfer watson-crick g⸱c dna base pair löwdin’s mechanism |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2020/09/Brovarets_4_20.pdf |
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