Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk
The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls w...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-05-01
|
| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867018300199 |
| _version_ | 1818033534366908416 |
|---|---|
| author | Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado |
| author_facet | Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado |
| author_sort | Milena Maria Moreira Guimarães |
| collection | DOAJ |
| description | The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p < 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p < 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p < 0.001) and LAP index (p < 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p < 0.01), BMI (r = 0.334; p < 0.01) and waist circumference (r = 0.452; p < 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV-negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients. Keywords: HIV, Hyperlipidemia, Atherosclerosis, Lipid accumulation product index, Cardiovascular risk, Insulin resistance |
| first_indexed | 2024-12-10T06:24:48Z |
| format | Article |
| id | doaj.art-9f9b032a4d1547e3af6542e803e93983 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-10T06:24:48Z |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-9f9b032a4d1547e3af6542e803e939832022-12-22T01:59:15ZengElsevierBrazilian Journal of Infectious Diseases1413-86702018-05-01223171176Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular riskMilena Maria Moreira Guimarães0Dirceu Bartolomeu Greco1Allyson Nogueira Moreira2Nathalia Sernizon Guimarães3Cláudia Maria Vilas Freire4Bruna Guimarães Rohlfs5Lucas José de Campos Machado6Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilCorresponding author.; Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilThe lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p < 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p < 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p < 0.001) and LAP index (p < 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p < 0.01), BMI (r = 0.334; p < 0.01) and waist circumference (r = 0.452; p < 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV-negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients. Keywords: HIV, Hyperlipidemia, Atherosclerosis, Lipid accumulation product index, Cardiovascular risk, Insulin resistancehttp://www.sciencedirect.com/science/article/pii/S1413867018300199 |
| spellingShingle | Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk Brazilian Journal of Infectious Diseases |
| title | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_full | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_fullStr | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_full_unstemmed | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_short | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_sort | lipid accumulation product index in hiv infected patients a marker of cardiovascular risk |
| url | http://www.sciencedirect.com/science/article/pii/S1413867018300199 |
| work_keys_str_mv | AT milenamariamoreiraguimaraes lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk AT dirceubartolomeugreco lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk AT allysonnogueiramoreira lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk AT nathaliasernizonguimaraes lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk AT claudiamariavilasfreire lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk AT brunaguimaraesrohlfs lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk AT lucasjosedecamposmachado lipidaccumulationproductindexinhivinfectedpatientsamarkerofcardiovascularrisk |