Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point
Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2411 |
| _version_ | 1797519848984543232 |
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| author | Juliana Portes Beatriz Bullón José Luis Quiles Maurizio Battino Pedro Bullón |
| author_facet | Juliana Portes Beatriz Bullón José Luis Quiles Maurizio Battino Pedro Bullón |
| author_sort | Juliana Portes |
| collection | DOAJ |
| description | Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meeting point among them. Inflammation hitherto includes vascular and tissue changes, but new technologies provide data at the intracellular level that could explain how the cells respond to the aggression more clearly. This review aims to emphasize the molecular pathophysiological mechanisms in patients with type 2 diabetes mellitus and periodontitis, which are marked by different impaired central regulators including mitochondrial dysfunction, impaired immune system and autophagy pathways, oxidative stress, and the crosstalk between adenosine monophosphate-activated protein kinase (AMPK) and the renin-angiotensin system (RAS). All of them are the shared background behind both diseases that could explain its relationship. These should be taken in consideration if we would like to improve the treatment outcomes. Currently, the main treatment strategies in diabetes try to reduce glycemia index as the most important aspect, and in periodontitis try to reduce the presence of oral bacteria. We propose to add to the therapeutic guidelines the handling of all the intracellular disorders to try to obtain better treatment success. |
| first_indexed | 2024-03-10T07:48:36Z |
| format | Article |
| id | doaj.art-9f9bd3e2347d490fb2046b239a4c4060 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:48:36Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9f9bd3e2347d490fb2046b239a4c40602023-11-22T12:25:43ZengMDPI AGCells2073-44092021-09-01109241110.3390/cells10092411Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting PointJuliana Portes0Beatriz Bullón1José Luis Quiles2Maurizio Battino3Pedro Bullón4Department of Periodontology, Dental School, University of Seville, C/Avicena, s/n, 41009 Seville, SpainDepartment of Periodontology, Dental School, University of Seville, C/Avicena, s/n, 41009 Seville, SpainBiomedical Research Center (CIBM), Department of Physiology, University Campus of Cartuja, Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, 18071 Granada, SpainDepartment of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche. Via Tronto 10A, 60126 Torrette di Ancona, ItalyDepartment of Periodontology, Dental School, University of Seville, C/Avicena, s/n, 41009 Seville, SpainDiabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meeting point among them. Inflammation hitherto includes vascular and tissue changes, but new technologies provide data at the intracellular level that could explain how the cells respond to the aggression more clearly. This review aims to emphasize the molecular pathophysiological mechanisms in patients with type 2 diabetes mellitus and periodontitis, which are marked by different impaired central regulators including mitochondrial dysfunction, impaired immune system and autophagy pathways, oxidative stress, and the crosstalk between adenosine monophosphate-activated protein kinase (AMPK) and the renin-angiotensin system (RAS). All of them are the shared background behind both diseases that could explain its relationship. These should be taken in consideration if we would like to improve the treatment outcomes. Currently, the main treatment strategies in diabetes try to reduce glycemia index as the most important aspect, and in periodontitis try to reduce the presence of oral bacteria. We propose to add to the therapeutic guidelines the handling of all the intracellular disorders to try to obtain better treatment success.https://www.mdpi.com/2073-4409/10/9/2411periodontal diseasediabetesmitochondrial dysfunctionoxidative stressAMPKautophagy |
| spellingShingle | Juliana Portes Beatriz Bullón José Luis Quiles Maurizio Battino Pedro Bullón Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point Cells periodontal disease diabetes mitochondrial dysfunction oxidative stress AMPK autophagy |
| title | Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point |
| title_full | Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point |
| title_fullStr | Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point |
| title_full_unstemmed | Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point |
| title_short | Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point |
| title_sort | diabetes mellitus and periodontitis share intracellular disorders as the main meeting point |
| topic | periodontal disease diabetes mitochondrial dysfunction oxidative stress AMPK autophagy |
| url | https://www.mdpi.com/2073-4409/10/9/2411 |
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