Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen c...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-03-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555246/?tool=EBI |
| _version_ | 1818574746688684032 |
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| author | Fatma Berri Guus F Rimmelzwaan Michel Hanss Emmanuel Albina Marie-Laure Foucault-Grunenwald Vuong B Lê Stella E Vogelzang-van Trierum Patrica Gil Eric Camerer Dominique Martinez Bruno Lina Roger Lijnen Peter Carmeliet Béatrice Riteau |
| author_facet | Fatma Berri Guus F Rimmelzwaan Michel Hanss Emmanuel Albina Marie-Laure Foucault-Grunenwald Vuong B Lê Stella E Vogelzang-van Trierum Patrica Gil Eric Camerer Dominique Martinez Bruno Lina Roger Lijnen Peter Carmeliet Béatrice Riteau |
| author_sort | Fatma Berri |
| collection | DOAJ |
| description | Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza. |
| first_indexed | 2024-12-15T00:30:38Z |
| format | Article |
| id | doaj.art-9f9c69898aa84d7dba0eade89776cc72 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-15T00:30:38Z |
| publishDate | 2013-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-9f9c69898aa84d7dba0eade89776cc722022-12-21T22:42:02ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742013-03-0193e100322910.1371/journal.ppat.1003229Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.Fatma BerriGuus F RimmelzwaanMichel HanssEmmanuel AlbinaMarie-Laure Foucault-GrunenwaldVuong B LêStella E Vogelzang-van TrierumPatrica GilEric CamererDominique MartinezBruno LinaRoger LijnenPeter CarmelietBéatrice RiteauDetrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555246/?tool=EBI |
| spellingShingle | Fatma Berri Guus F Rimmelzwaan Michel Hanss Emmanuel Albina Marie-Laure Foucault-Grunenwald Vuong B Lê Stella E Vogelzang-van Trierum Patrica Gil Eric Camerer Dominique Martinez Bruno Lina Roger Lijnen Peter Carmeliet Béatrice Riteau Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. PLoS Pathogens |
| title | Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. |
| title_full | Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. |
| title_fullStr | Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. |
| title_full_unstemmed | Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. |
| title_short | Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. |
| title_sort | plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555246/?tool=EBI |
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