Exosomal non-coding RNAs have a significant effect on tumor metastasis
Exosomes are produced by the majority of eukaryotic cells and are capable of transporting a variety of substances, including non-coding RNAs, between cells. Metastasis is a significant cause of death from cancer. Numerous studies have established an important role for exosomal non-coding RNAs in tum...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253122001470 |
| _version_ | 1828329419310104576 |
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| author | Di Wang Wei Zhang Chunxi Zhang Liwei Wang Heng Chen Jianbin Xu |
| author_facet | Di Wang Wei Zhang Chunxi Zhang Liwei Wang Heng Chen Jianbin Xu |
| author_sort | Di Wang |
| collection | DOAJ |
| description | Exosomes are produced by the majority of eukaryotic cells and are capable of transporting a variety of substances, including non-coding RNAs, between cells. Metastasis is a significant cause of death from cancer. Numerous studies have established an important role for exosomal non-coding RNAs in tumor metastasis. Exosomal non-coding RNAs from a variety of cells have been shown to affect tumor metastasis via several mechanisms. Exosomes transmit non-coding RNAs between tumor cells, fibroblasts, endothelial cells, and immune cells within the tumor microenvironment. Exosomal non-coding RNAs also have an effect on epithelial-mesenchymal transition, angiogenesis, and lymphangiogenesis. Exosomes derived from tumor cells have the ability to transport non-coding RNAs to distant organs, thereby facilitating the formation of the metastatic niche. Due to their role in tumor metastasis, exosomal non-coding RNAs have the potential to serve as diagnostic or prognostic markers as well as therapeutic targets for tumors. The purpose of this paper is to review and discuss the mechanisms of exosomal non-coding RNAs, their role in tumor metastasis, and their clinical utility, aiming to establish new directions for tumor metastasis, diagnosis, and treatment research. |
| first_indexed | 2024-04-13T20:24:01Z |
| format | Article |
| id | doaj.art-9f9ebdeb692a42c39bb3ca4b2d2dcb1f |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-04-13T20:24:01Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-9f9ebdeb692a42c39bb3ca4b2d2dcb1f2022-12-22T02:31:25ZengElsevierMolecular Therapy: Nucleic Acids2162-25312022-09-01291635Exosomal non-coding RNAs have a significant effect on tumor metastasisDi Wang0Wei Zhang1Chunxi Zhang2Liwei Wang3Heng Chen4Jianbin Xu5Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. ChinaSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. ChinaWomen’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. ChinaSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. ChinaShenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Nanshan District, Shenzhen 518060, P.R. China; Corresponding author Heng Chen, Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Nanshan District, Shenzhen 518060, P.R. China.Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China; Corresponding author Jianbin Xu, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.Exosomes are produced by the majority of eukaryotic cells and are capable of transporting a variety of substances, including non-coding RNAs, between cells. Metastasis is a significant cause of death from cancer. Numerous studies have established an important role for exosomal non-coding RNAs in tumor metastasis. Exosomal non-coding RNAs from a variety of cells have been shown to affect tumor metastasis via several mechanisms. Exosomes transmit non-coding RNAs between tumor cells, fibroblasts, endothelial cells, and immune cells within the tumor microenvironment. Exosomal non-coding RNAs also have an effect on epithelial-mesenchymal transition, angiogenesis, and lymphangiogenesis. Exosomes derived from tumor cells have the ability to transport non-coding RNAs to distant organs, thereby facilitating the formation of the metastatic niche. Due to their role in tumor metastasis, exosomal non-coding RNAs have the potential to serve as diagnostic or prognostic markers as well as therapeutic targets for tumors. The purpose of this paper is to review and discuss the mechanisms of exosomal non-coding RNAs, their role in tumor metastasis, and their clinical utility, aiming to establish new directions for tumor metastasis, diagnosis, and treatment research.http://www.sciencedirect.com/science/article/pii/S2162253122001470MT: Non-coding RNAsexosometumor metastasisnon-coding RNAmicroenvironmentimmunity |
| spellingShingle | Di Wang Wei Zhang Chunxi Zhang Liwei Wang Heng Chen Jianbin Xu Exosomal non-coding RNAs have a significant effect on tumor metastasis Molecular Therapy: Nucleic Acids MT: Non-coding RNAs exosome tumor metastasis non-coding RNA microenvironment immunity |
| title | Exosomal non-coding RNAs have a significant effect on tumor metastasis |
| title_full | Exosomal non-coding RNAs have a significant effect on tumor metastasis |
| title_fullStr | Exosomal non-coding RNAs have a significant effect on tumor metastasis |
| title_full_unstemmed | Exosomal non-coding RNAs have a significant effect on tumor metastasis |
| title_short | Exosomal non-coding RNAs have a significant effect on tumor metastasis |
| title_sort | exosomal non coding rnas have a significant effect on tumor metastasis |
| topic | MT: Non-coding RNAs exosome tumor metastasis non-coding RNA microenvironment immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2162253122001470 |
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