Different Cases of SARS-CoV-2 Infection and Its Impact on Health and Economy with Special Emphasis on Antiviral Drug Targets
COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economic disaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS and MERS it’s structural and sequence similarity has abled scientists for repurposing of popular drugs like...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2020-05-01
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| Series: | Journal of Pure and Applied Microbiology |
| Subjects: | |
| Online Access: | https://microbiologyjournal.org/different-cases-of-sars-cov-2-infection-and-its-impact-on-health-and-economy-with-special-emphasis-on-antiviral-drug-targets/ |
| Summary: | COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economic
disaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS and
MERS it’s structural and sequence similarity has abled scientists for repurposing of popular drugs like
hydroxychloroquine, cloroquine and also scavenging for lead molecules by in-silico and in-vivo or in-vitro
approach. The potent drug targets are ACE2; spike protein binding receptor to host cell surface, Mpro;
proteo-lytic polyprotein processing enzymes needed for virion maturation and RdRp; RNA dependent
RNA polymerase needed for RNA replication. The recent trend focuses on the fact that cocktail of anticorona virus treatment will be available soon by broad spectrum antiviral compounds. It takes time
to develop such drug targets till then social distancing and following of hygiene are the only way to
thrive well. This article incorporates the present World scenario related to COVID infection, focuses
on its origin and also future possibilities for a COVID free future. |
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| ISSN: | 0973-7510 2581-690X |