A temporal threshold for formaldehyde crosslinking and fixation.
Formaldehyde crosslinking is in widespread use as a biological fixative for microscopy and molecular biology. An assumption behind its use is that most biologically meaningful interactions are preserved by crosslinking, but the minimum length of time required for an interaction to become fixed has n...
Main Authors: | Lars Schmiedeberg, Pete Skene, Aimée Deaton, Adrian Bird |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2645674?pdf=render |
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