An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model
Abstract Retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has been shown to induce neuroprotective changes in the retina capable of slowing down the progression of retinal bl...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40547-1 |
| _version_ | 1797452601576390656 |
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| author | Alejandra Gonzalez Calle Javad Paknahad Dimitrios Pollalis Pragya Kosta Biju Thomas Ben Yi Tew Bodour Salhia Stan Louie Gianluca Lazzi Mark Humayun |
| author_facet | Alejandra Gonzalez Calle Javad Paknahad Dimitrios Pollalis Pragya Kosta Biju Thomas Ben Yi Tew Bodour Salhia Stan Louie Gianluca Lazzi Mark Humayun |
| author_sort | Alejandra Gonzalez Calle |
| collection | DOAJ |
| description | Abstract Retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has been shown to induce neuroprotective changes in the retina capable of slowing down the progression of retinal blindness. In this work, a multi-scale computational model and modeling platform were used to design electrical stimulation strategies to better target the bipolar cells (BCs), that along with photoreceptors are affected at the early stage of retinal degenerative diseases. Our computational findings revealed that biphasic stimulus pulses of long pulse duration could decrease the activation threshold of BCs, and the differential stimulus threshold between ganglion cells (RGCs) and BCs, offering the potential of targeting the BCs during the early phase of degeneration. In vivo experiments were performed to evaluate the electrode placement and parameters found to target bipolar cells and evaluate the safety and efficacy of the treatment. Results indicate that the proposed transcorneal Electrical Stimulation (TES) strategy can attenuate retinal degeneration in a Royal College of Surgeon (RCS) rodent model, offering the potential to translate this work to clinical practice. |
| first_indexed | 2024-03-09T15:11:00Z |
| format | Article |
| id | doaj.art-9fa01fa1d3c444e8a3ccb449cdad8b56 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:11:00Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9fa01fa1d3c444e8a3ccb449cdad8b562023-11-26T13:22:56ZengNature PortfolioScientific Reports2045-23222023-09-0113111010.1038/s41598-023-40547-1An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal modelAlejandra Gonzalez Calle0Javad Paknahad1Dimitrios Pollalis2Pragya Kosta3Biju Thomas4Ben Yi Tew5Bodour Salhia6Stan Louie7Gianluca Lazzi8Mark Humayun9Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern CaliforniaDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern CaliforniaAbstract Retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has been shown to induce neuroprotective changes in the retina capable of slowing down the progression of retinal blindness. In this work, a multi-scale computational model and modeling platform were used to design electrical stimulation strategies to better target the bipolar cells (BCs), that along with photoreceptors are affected at the early stage of retinal degenerative diseases. Our computational findings revealed that biphasic stimulus pulses of long pulse duration could decrease the activation threshold of BCs, and the differential stimulus threshold between ganglion cells (RGCs) and BCs, offering the potential of targeting the BCs during the early phase of degeneration. In vivo experiments were performed to evaluate the electrode placement and parameters found to target bipolar cells and evaluate the safety and efficacy of the treatment. Results indicate that the proposed transcorneal Electrical Stimulation (TES) strategy can attenuate retinal degeneration in a Royal College of Surgeon (RCS) rodent model, offering the potential to translate this work to clinical practice.https://doi.org/10.1038/s41598-023-40547-1 |
| spellingShingle | Alejandra Gonzalez Calle Javad Paknahad Dimitrios Pollalis Pragya Kosta Biju Thomas Ben Yi Tew Bodour Salhia Stan Louie Gianluca Lazzi Mark Humayun An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model Scientific Reports |
| title | An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model |
| title_full | An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model |
| title_fullStr | An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model |
| title_full_unstemmed | An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model |
| title_short | An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model |
| title_sort | extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model |
| url | https://doi.org/10.1038/s41598-023-40547-1 |
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