Three‐dimensional multicellular biomaterial platforms for biomedical application
Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or biomaterials have been widely applied in biomedical fields for the regeneration of complex tissues, the exploration of cell crosstalk, and the establishment of tissue physiological and pathological models. Compared with...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Interdisciplinary Materials |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/idm2.12122 |
| _version_ | 1797644356390223872 |
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| author | Jianxin Hao Chen Qin Chengtie Wu |
| author_facet | Jianxin Hao Chen Qin Chengtie Wu |
| author_sort | Jianxin Hao |
| collection | DOAJ |
| description | Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or biomaterials have been widely applied in biomedical fields for the regeneration of complex tissues, the exploration of cell crosstalk, and the establishment of tissue physiological and pathological models. Compared with the traditional 2D culture methods, the 3D multicellular platforms are easier to adjust the components and structures of extracellular matrix (ECM) because of the synthesis of ECM by cells and the use of biomaterials. Moreover, the 3D multicellular platforms also can customize the cell distribution and precisely design micro and macro structures of the systems. Based on these typical advantages of 3D multicellular platforms and their increasingly important position in the biomedical field, this review summarizes the present 3D multicellular platforms. Herein, current 3D multicellular platforms are divided into two major types: scaffold‐free and scaffold‐based 3D multicellular platforms. The specific characteristics and applications of different types of 3D multicellular platforms are thoroughly introduced to help readers understand how different models affect and regulate cell behaviors and inspire researchers on how to select and design suitable 3D multicellular platforms according to different application scenarios. |
| first_indexed | 2024-03-11T14:29:22Z |
| format | Article |
| id | doaj.art-9fa11c069ad54318a154478c6dae9c10 |
| institution | Directory Open Access Journal |
| issn | 2767-441X |
| language | English |
| last_indexed | 2024-03-11T14:29:22Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Materials |
| spelling | doaj.art-9fa11c069ad54318a154478c6dae9c102023-10-31T10:58:02ZengWileyInterdisciplinary Materials2767-441X2023-09-012571473410.1002/idm2.12122Three‐dimensional multicellular biomaterial platforms for biomedical applicationJianxin Hao0Chen Qin1Chengtie Wu2State Key Laboratory of High‐Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai People's Republic of ChinaState Key Laboratory of High‐Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai People's Republic of ChinaState Key Laboratory of High‐Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai People's Republic of ChinaAbstract The three‐dimensional (3D) multicellular platforms prepared by cells or biomaterials have been widely applied in biomedical fields for the regeneration of complex tissues, the exploration of cell crosstalk, and the establishment of tissue physiological and pathological models. Compared with the traditional 2D culture methods, the 3D multicellular platforms are easier to adjust the components and structures of extracellular matrix (ECM) because of the synthesis of ECM by cells and the use of biomaterials. Moreover, the 3D multicellular platforms also can customize the cell distribution and precisely design micro and macro structures of the systems. Based on these typical advantages of 3D multicellular platforms and their increasingly important position in the biomedical field, this review summarizes the present 3D multicellular platforms. Herein, current 3D multicellular platforms are divided into two major types: scaffold‐free and scaffold‐based 3D multicellular platforms. The specific characteristics and applications of different types of 3D multicellular platforms are thoroughly introduced to help readers understand how different models affect and regulate cell behaviors and inspire researchers on how to select and design suitable 3D multicellular platforms according to different application scenarios.https://doi.org/10.1002/idm2.121223D multicellular platformbiomedical applicationscaffold‐based methodscaffold‐free method |
| spellingShingle | Jianxin Hao Chen Qin Chengtie Wu Three‐dimensional multicellular biomaterial platforms for biomedical application Interdisciplinary Materials 3D multicellular platform biomedical application scaffold‐based method scaffold‐free method |
| title | Three‐dimensional multicellular biomaterial platforms for biomedical application |
| title_full | Three‐dimensional multicellular biomaterial platforms for biomedical application |
| title_fullStr | Three‐dimensional multicellular biomaterial platforms for biomedical application |
| title_full_unstemmed | Three‐dimensional multicellular biomaterial platforms for biomedical application |
| title_short | Three‐dimensional multicellular biomaterial platforms for biomedical application |
| title_sort | three dimensional multicellular biomaterial platforms for biomedical application |
| topic | 3D multicellular platform biomedical application scaffold‐based method scaffold‐free method |
| url | https://doi.org/10.1002/idm2.12122 |
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