Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study
Abstract Objectives Pulmonary embolism (PE) is a life‐threatening complication that can occur in patients with lung cancer. In this study, we aimed to identify risk factors and examine the clinical characteristics of advanced lung cancer patients with PE. Methods We conducted a retrospective review...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13692 |
| _version_ | 1797668918820601856 |
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| author | Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian‐an Huang Yixin Lian |
| author_facet | Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian‐an Huang Yixin Lian |
| author_sort | Yongkang Huang |
| collection | DOAJ |
| description | Abstract Objectives Pulmonary embolism (PE) is a life‐threatening complication that can occur in patients with lung cancer. In this study, we aimed to identify risk factors and examine the clinical characteristics of advanced lung cancer patients with PE. Methods We conducted a retrospective review of patients admitted to our two hospitals between January 2020 and June 2022. The case group consisted of patients with lung cancer and PE, and a closely matched control group was included to identify risk factors. Statistical analysis was conducted using R language. Results A total of 4957 patients were reviewed, and 162 patients (comprising 54 cases and 108 controls) were included in this study. The prevalence of lung cancer with PE in the study population was 1.08%. The majority of patients were male, and the most common histological subtype was adenocarcinoma (67%), followed by squamous cell carcinoma, small cell carcinoma, and poorly differentiated non‐small cell lung cancer. The majority of patients had a high performance status (PS) score, with 50% experiencing respiratory failure (mainly hypoxia) and 33% with deep vein thrombosis (DVT). Forty‐eight percent of patients were diagnosed with concurrent PE. Further analysis showed that PE was an independent predictor of poor survival, and a PS score of >1 was an independent risk factor for PE in patients with lung cancer. Conclusion Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE. |
| first_indexed | 2024-03-11T20:36:32Z |
| format | Article |
| id | doaj.art-9fa1b38ed80544fe8c2fca0567218679 |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-03-11T20:36:32Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-9fa1b38ed80544fe8c2fca05672186792023-10-02T06:33:21ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2023-10-0117101048105710.1111/crj.13692Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control studyYongkang Huang0Shiyuan Gao1Ting Li2Beilei Zhang3Juan Du4Yajuan Qian5Yufei Xing6Tong Zhou7Minhua Shi8Jian‐an Huang9Yixin Lian10Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaAbstract Objectives Pulmonary embolism (PE) is a life‐threatening complication that can occur in patients with lung cancer. In this study, we aimed to identify risk factors and examine the clinical characteristics of advanced lung cancer patients with PE. Methods We conducted a retrospective review of patients admitted to our two hospitals between January 2020 and June 2022. The case group consisted of patients with lung cancer and PE, and a closely matched control group was included to identify risk factors. Statistical analysis was conducted using R language. Results A total of 4957 patients were reviewed, and 162 patients (comprising 54 cases and 108 controls) were included in this study. The prevalence of lung cancer with PE in the study population was 1.08%. The majority of patients were male, and the most common histological subtype was adenocarcinoma (67%), followed by squamous cell carcinoma, small cell carcinoma, and poorly differentiated non‐small cell lung cancer. The majority of patients had a high performance status (PS) score, with 50% experiencing respiratory failure (mainly hypoxia) and 33% with deep vein thrombosis (DVT). Forty‐eight percent of patients were diagnosed with concurrent PE. Further analysis showed that PE was an independent predictor of poor survival, and a PS score of >1 was an independent risk factor for PE in patients with lung cancer. Conclusion Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE.https://doi.org/10.1111/crj.13692characteristiclung cancerprevalencerisk factorssurvival |
| spellingShingle | Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian‐an Huang Yixin Lian Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study The Clinical Respiratory Journal characteristic lung cancer prevalence risk factors survival |
| title | Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study |
| title_full | Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study |
| title_fullStr | Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study |
| title_full_unstemmed | Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study |
| title_short | Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross‐sectional, case–control study |
| title_sort | characteristics and risk factors for advanced lung cancer with pulmonary embolism a cross sectional case control study |
| topic | characteristic lung cancer prevalence risk factors survival |
| url | https://doi.org/10.1111/crj.13692 |
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