Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed. Overlooked in these approaches is the loss of one co...

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Bibliographic Details
Main Authors: Ajai J. Pulianmackal, Kiriaki Kanakousaki, Kerry Flegel, Olga G. Grushko, Ella Gourley, Emily Rozich, Laura A. Buttitta
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Disease Models & Mechanisms
Subjects:
drosophila wing
nuclear pore complex
ribosome biogenesis
jnk signaling
apoptosis
compensatory proliferation
Online Access:http://dmm.biologists.org/content/15/3/dmm049234

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