Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations
Tocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450 mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm o...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-03-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614000024 |
| _version_ | 1818647980466503680 |
|---|---|
| author | Astrid M. Drotleff Christoph Bohnsack Inga Schneider Andreas Hahn Waldemar Ternes |
| author_facet | Astrid M. Drotleff Christoph Bohnsack Inga Schneider Andreas Hahn Waldemar Ternes |
| author_sort | Astrid M. Drotleff |
| collection | DOAJ |
| description | Tocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450 mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm oil (both also low in tocopherols) in seven healthy male human subjects 0–24 h post-dose. The maximum α-tocotrienol plasma concentration (22.57 ± 2.84 mg/L, 2.1 ± 0.3 h) was significantly (p < 0.001) higher for barley oil than for palm oil (5.25 ± 0.99 mg/L, 2.3 ± 0.6 h). The area under the curve (0–24 h) of total (α-, β-, γ-, δ-) tocotrienols was significantly (p < 0.001) (2.6fold) higher in the barley oil group, where the total (0–24 h) urinary metabolites carboxyethyl-hydroxychromans (CEHC) and carboxymethylbutyl-hydroxychromans (CMBHC) were also significantly (p < 0.05) (1.2fold) higher (163.9 ± 19.2 μmol). Thus, due to its high proportion of α-tocotrienol, which is known for its preferential absorption, the barley oil formulation was superior to the commercial palm oil formulation. This provides support for the application of tocotrienols from barley oil in the functional foods field. |
| first_indexed | 2024-12-17T01:11:09Z |
| format | Article |
| id | doaj.art-9fa2435e61c445209fcaa8ac32946f9c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T01:11:09Z |
| publishDate | 2014-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9fa2435e61c445209fcaa8ac32946f9c2022-12-21T22:09:09ZengElsevierJournal of Functional Foods1756-46462014-03-017150160Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulationsAstrid M. Drotleff0Christoph Bohnsack1Inga Schneider2Andreas Hahn3Waldemar Ternes4Department of Analytical Chemistry, Institute of Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15/123, D-30173 Hannover, Germany; Corresponding author. Tel.: +49 5118567365.Department of Analytical Chemistry, Institute of Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15/123, D-30173 Hannover, GermanyInstitute of Food Science and Human Nutrition, Leibniz University of Hannover, Am Kleinen Felde 30, D-30167 Hannover, GermanyInstitute of Food Science and Human Nutrition, Leibniz University of Hannover, Am Kleinen Felde 30, D-30167 Hannover, GermanyDepartment of Analytical Chemistry, Institute of Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15/123, D-30173 Hannover, GermanyTocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450 mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm oil (both also low in tocopherols) in seven healthy male human subjects 0–24 h post-dose. The maximum α-tocotrienol plasma concentration (22.57 ± 2.84 mg/L, 2.1 ± 0.3 h) was significantly (p < 0.001) higher for barley oil than for palm oil (5.25 ± 0.99 mg/L, 2.3 ± 0.6 h). The area under the curve (0–24 h) of total (α-, β-, γ-, δ-) tocotrienols was significantly (p < 0.001) (2.6fold) higher in the barley oil group, where the total (0–24 h) urinary metabolites carboxyethyl-hydroxychromans (CEHC) and carboxymethylbutyl-hydroxychromans (CMBHC) were also significantly (p < 0.05) (1.2fold) higher (163.9 ± 19.2 μmol). Thus, due to its high proportion of α-tocotrienol, which is known for its preferential absorption, the barley oil formulation was superior to the commercial palm oil formulation. This provides support for the application of tocotrienols from barley oil in the functional foods field.http://www.sciencedirect.com/science/article/pii/S1756464614000024Barley extractTocotrienol compositionVitamin EHuman oral bioavailabilityBlood plasmaUrinary metabolites |
| spellingShingle | Astrid M. Drotleff Christoph Bohnsack Inga Schneider Andreas Hahn Waldemar Ternes Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations Journal of Functional Foods Barley extract Tocotrienol composition Vitamin E Human oral bioavailability Blood plasma Urinary metabolites |
| title | Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations |
| title_full | Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations |
| title_fullStr | Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations |
| title_full_unstemmed | Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations |
| title_short | Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations |
| title_sort | human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol rich tocopherol low barley oil and palm oil formulations |
| topic | Barley extract Tocotrienol composition Vitamin E Human oral bioavailability Blood plasma Urinary metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614000024 |
| work_keys_str_mv | AT astridmdrotleff humanoralbioavailabilityandpharmacokineticsoftocotrienolsfromtocotrienolrichtocopherollowbarleyoilandpalmoilformulations AT christophbohnsack humanoralbioavailabilityandpharmacokineticsoftocotrienolsfromtocotrienolrichtocopherollowbarleyoilandpalmoilformulations AT ingaschneider humanoralbioavailabilityandpharmacokineticsoftocotrienolsfromtocotrienolrichtocopherollowbarleyoilandpalmoilformulations AT andreashahn humanoralbioavailabilityandpharmacokineticsoftocotrienolsfromtocotrienolrichtocopherollowbarleyoilandpalmoilformulations AT waldemarternes humanoralbioavailabilityandpharmacokineticsoftocotrienolsfromtocotrienolrichtocopherollowbarleyoilandpalmoilformulations |