The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer
Abstract Purpose Colon cancer (CC) is a very common gastrointestinal tumor that is prone to invasion and metastasis in the late stage. This study aims to observe the expression of Na+/Ca2+ exchangers (NCXs) and analyze the correlation between NCXs and the prognosis of CC. Methods Specimens of 111 st...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-021-02284-5 |
| _version_ | 1819105922581004288 |
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| author | Zhixiu Xia Changliang Wang Hong Zhang |
| author_facet | Zhixiu Xia Changliang Wang Hong Zhang |
| author_sort | Zhixiu Xia |
| collection | DOAJ |
| description | Abstract Purpose Colon cancer (CC) is a very common gastrointestinal tumor that is prone to invasion and metastasis in the late stage. This study aims to observe the expression of Na+/Ca2+ exchangers (NCXs) and analyze the correlation between NCXs and the prognosis of CC. Methods Specimens of 111 stage II–IV CC patients were collected. We used western blotting, qPCR, and immunohistochemical staining to observe the distributions and expression levels of NCX isoforms (NCX1, NCX2, and NCX3) in CC and distal normal tissues. Cox proportional hazards models were used to assess prognostic factors for patients. Results The expression of NCXs in most tumor specimens was lower than that in normal tissues. The NCX expression levels in tumor tissues from the primary tumor, local lymph node metastasis sites, and distant liver metastasis sites were increasingly significantly lower than those in normal tissues. The results of the Kaplan-Meier survival curves showed that the downregulation of any NCX isoform was closely related to the worse prognosis of advanced CC. Conclusion NCXs can be used as independent prognostic factors for CC. Our research results are expected to provide new targets for the treatment of CC. |
| first_indexed | 2024-12-22T02:29:57Z |
| format | Article |
| id | doaj.art-9fa279a948b74c2ea5c7111959656e93 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-22T02:29:57Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-9fa279a948b74c2ea5c7111959656e932022-12-21T18:41:54ZengBMCWorld Journal of Surgical Oncology1477-78192021-06-0119111410.1186/s12957-021-02284-5The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancerZhixiu Xia0Changliang Wang1Hong Zhang2Colorectal Tumor Surgery Ward, Department of General Surgery, Shengjing Hospital of China Medical UniversityThe People’s Procuratorate of Liaoning Province Judicial Authentication CenterColorectal Tumor Surgery Ward, Department of General Surgery, Shengjing Hospital of China Medical UniversityAbstract Purpose Colon cancer (CC) is a very common gastrointestinal tumor that is prone to invasion and metastasis in the late stage. This study aims to observe the expression of Na+/Ca2+ exchangers (NCXs) and analyze the correlation between NCXs and the prognosis of CC. Methods Specimens of 111 stage II–IV CC patients were collected. We used western blotting, qPCR, and immunohistochemical staining to observe the distributions and expression levels of NCX isoforms (NCX1, NCX2, and NCX3) in CC and distal normal tissues. Cox proportional hazards models were used to assess prognostic factors for patients. Results The expression of NCXs in most tumor specimens was lower than that in normal tissues. The NCX expression levels in tumor tissues from the primary tumor, local lymph node metastasis sites, and distant liver metastasis sites were increasingly significantly lower than those in normal tissues. The results of the Kaplan-Meier survival curves showed that the downregulation of any NCX isoform was closely related to the worse prognosis of advanced CC. Conclusion NCXs can be used as independent prognostic factors for CC. Our research results are expected to provide new targets for the treatment of CC.https://doi.org/10.1186/s12957-021-02284-5NCXColon cancerCalcium ionPrognosis |
| spellingShingle | Zhixiu Xia Changliang Wang Hong Zhang The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer World Journal of Surgical Oncology NCX Colon cancer Calcium ion Prognosis |
| title | The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer |
| title_full | The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer |
| title_fullStr | The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer |
| title_full_unstemmed | The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer |
| title_short | The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer |
| title_sort | downregulation of ncxs is positively correlated with the prognosis of stage ii iv colon cancer |
| topic | NCX Colon cancer Calcium ion Prognosis |
| url | https://doi.org/10.1186/s12957-021-02284-5 |
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