Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions
Mitochondrial porins, also known as voltage-dependent anion selective channels (VDACs), are pore-forming molecules of the outer mitochondrial membranes, involved in the regulation of metabolic flux between cytosol and mitochondria. Playing such an essential role, VDAC proteins are evolutionary conse...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.675708/full |
| _version_ | 1818459354672660480 |
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| author | Maria Carmela Di Rosa Francesca Guarino Francesca Guarino Stefano Conti Nibali Andrea Magrì Andrea Magrì Vito De Pinto Vito De Pinto |
| author_facet | Maria Carmela Di Rosa Francesca Guarino Francesca Guarino Stefano Conti Nibali Andrea Magrì Andrea Magrì Vito De Pinto Vito De Pinto |
| author_sort | Maria Carmela Di Rosa |
| collection | DOAJ |
| description | Mitochondrial porins, also known as voltage-dependent anion selective channels (VDACs), are pore-forming molecules of the outer mitochondrial membranes, involved in the regulation of metabolic flux between cytosol and mitochondria. Playing such an essential role, VDAC proteins are evolutionary conserved and isoforms are present in numerous species. The quest for specific function(s) related to the raise of multiple isoforms is an intriguing theme. The yeast Saccharomyces cerevisiae genome is endowed with two different VDAC genes encoding for two distinct porin isoforms, definitely less characterized in comparison to mammalian counterpart. While yVDAC1 has been extensively studied, the second isoform, yVDAC2, is much less expressed, and has a still misunderstood function. This review will recapitulate the known and poorly known information in the literature, in the light of the growing interest about the features of VDAC isoforms in the cell. |
| first_indexed | 2024-12-14T23:13:01Z |
| format | Article |
| id | doaj.art-9fa2881a835f430bb13a7ca2316ba23d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T23:13:01Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-9fa2881a835f430bb13a7ca2316ba23d2022-12-21T22:44:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-05-011210.3389/fphys.2021.675708675708Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and FunctionsMaria Carmela Di Rosa0Francesca Guarino1Francesca Guarino2Stefano Conti Nibali3Andrea Magrì4Andrea Magrì5Vito De Pinto6Vito De Pinto7Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italywe.MitoBiotech S.R.L., Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italywe.MitoBiotech S.R.L., Catania, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Catania, Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italywe.MitoBiotech S.R.L., Catania, ItalyMitochondrial porins, also known as voltage-dependent anion selective channels (VDACs), are pore-forming molecules of the outer mitochondrial membranes, involved in the regulation of metabolic flux between cytosol and mitochondria. Playing such an essential role, VDAC proteins are evolutionary conserved and isoforms are present in numerous species. The quest for specific function(s) related to the raise of multiple isoforms is an intriguing theme. The yeast Saccharomyces cerevisiae genome is endowed with two different VDAC genes encoding for two distinct porin isoforms, definitely less characterized in comparison to mammalian counterpart. While yVDAC1 has been extensively studied, the second isoform, yVDAC2, is much less expressed, and has a still misunderstood function. This review will recapitulate the known and poorly known information in the literature, in the light of the growing interest about the features of VDAC isoforms in the cell.https://www.frontiersin.org/articles/10.3389/fphys.2021.675708/fullporinVDACmitochondriaelectrophyiologyyeastouter mitochondrial membrane |
| spellingShingle | Maria Carmela Di Rosa Francesca Guarino Francesca Guarino Stefano Conti Nibali Andrea Magrì Andrea Magrì Vito De Pinto Vito De Pinto Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions Frontiers in Physiology porin VDAC mitochondria electrophyiology yeast outer mitochondrial membrane |
| title | Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions |
| title_full | Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions |
| title_fullStr | Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions |
| title_full_unstemmed | Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions |
| title_short | Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions |
| title_sort | voltage dependent anion selective channel isoforms in yeast expression structure and functions |
| topic | porin VDAC mitochondria electrophyiology yeast outer mitochondrial membrane |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.675708/full |
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