Fecal biomarkers: Non-invasive diagnosis of colorectal cancer
Colorectal cancer (CRC) is the third most common cancer in the world in terms of morbidity and mortality, which brings great health hazards and economic burdens to patients and society. A fecal examination is an effective method for clinical examination and the most commonly used method for the cens...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.971930/full |
| _version_ | 1811305345397555200 |
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| author | Qian Ding Xiangxu Kong Weilong Zhong Wentian Liu |
| author_facet | Qian Ding Xiangxu Kong Weilong Zhong Wentian Liu |
| author_sort | Qian Ding |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common cancer in the world in terms of morbidity and mortality, which brings great health hazards and economic burdens to patients and society. A fecal examination is an effective method for clinical examination and the most commonly used method for the census. It is simple, non-invasive, and suitable for large-scale population screening. With the development of molecular biology, lots of efforts have been made to discover new fecal biomarkers for the early screening of colorectal cancer. In this review, we summarize and discuss the recent advances of fecal biomarkers for CRC screening or diagnosis, including DNA biomarkers, RNA biomarkers, protein biomarkers, gut microbes and volatile organic compounds focusing on their diagnostic evaluation for CRC, which can provide a basis for the further development of new and effective CRC fecal screening and early diagnosis techniques. |
| first_indexed | 2024-04-13T08:24:47Z |
| format | Article |
| id | doaj.art-9fa35096b176467dacad73f4b61d131f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T08:24:47Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9fa35096b176467dacad73f4b61d131f2022-12-22T02:54:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.971930971930Fecal biomarkers: Non-invasive diagnosis of colorectal cancerQian DingXiangxu KongWeilong ZhongWentian LiuColorectal cancer (CRC) is the third most common cancer in the world in terms of morbidity and mortality, which brings great health hazards and economic burdens to patients and society. A fecal examination is an effective method for clinical examination and the most commonly used method for the census. It is simple, non-invasive, and suitable for large-scale population screening. With the development of molecular biology, lots of efforts have been made to discover new fecal biomarkers for the early screening of colorectal cancer. In this review, we summarize and discuss the recent advances of fecal biomarkers for CRC screening or diagnosis, including DNA biomarkers, RNA biomarkers, protein biomarkers, gut microbes and volatile organic compounds focusing on their diagnostic evaluation for CRC, which can provide a basis for the further development of new and effective CRC fecal screening and early diagnosis techniques.https://www.frontiersin.org/articles/10.3389/fonc.2022.971930/fullfecal biomarkersdiagnosisCRCnon-invasivescreening |
| spellingShingle | Qian Ding Xiangxu Kong Weilong Zhong Wentian Liu Fecal biomarkers: Non-invasive diagnosis of colorectal cancer Frontiers in Oncology fecal biomarkers diagnosis CRC non-invasive screening |
| title | Fecal biomarkers: Non-invasive diagnosis of colorectal cancer |
| title_full | Fecal biomarkers: Non-invasive diagnosis of colorectal cancer |
| title_fullStr | Fecal biomarkers: Non-invasive diagnosis of colorectal cancer |
| title_full_unstemmed | Fecal biomarkers: Non-invasive diagnosis of colorectal cancer |
| title_short | Fecal biomarkers: Non-invasive diagnosis of colorectal cancer |
| title_sort | fecal biomarkers non invasive diagnosis of colorectal cancer |
| topic | fecal biomarkers diagnosis CRC non-invasive screening |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.971930/full |
| work_keys_str_mv | AT qianding fecalbiomarkersnoninvasivediagnosisofcolorectalcancer AT xiangxukong fecalbiomarkersnoninvasivediagnosisofcolorectalcancer AT weilongzhong fecalbiomarkersnoninvasivediagnosisofcolorectalcancer AT wentianliu fecalbiomarkersnoninvasivediagnosisofcolorectalcancer |