In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis
We aimed to explore triggering receptor expressed on myeloid cells-1 (TREM-1) activation in familial Mediterranean fever (FMF), the most frequent monogenic auto-inflammatory disease, through the measurement of its serum soluble form, named sTREM-1. Blood samples from patients with FMF according to L...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-11-01
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| Series: | Innate Immunity |
| Online Access: | https://doi.org/10.1177/1753425919870847 |
| _version_ | 1818189195176312832 |
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| author | Clémence Gorlier Jérémie Sellam Ludivine Laurans Tabassome Simon Irina Giurgea Jean-Philippe Bastard Soraya Fellahi Samuel Deshayes Gilles Grateau Hafid Ait Oufella Sophie Georgin-Lavialle |
| author_facet | Clémence Gorlier Jérémie Sellam Ludivine Laurans Tabassome Simon Irina Giurgea Jean-Philippe Bastard Soraya Fellahi Samuel Deshayes Gilles Grateau Hafid Ait Oufella Sophie Georgin-Lavialle |
| author_sort | Clémence Gorlier |
| collection | DOAJ |
| description | We aimed to explore triggering receptor expressed on myeloid cells-1 (TREM-1) activation in familial Mediterranean fever (FMF), the most frequent monogenic auto-inflammatory disease, through the measurement of its serum soluble form, named sTREM-1. Blood samples from patients with FMF according to Livneh criteria followed in the French FMF national center and carrying two pathogenic MEFV mutations were collected. Serum level of sTREM-1 was assessed using ELISA. Demographic data, presence of FMF attack, association with histologically proven AA amyloidosis, and blood levels of C-reactive protein (CRP), serum amyloid A (SAA) protein, and creatinine were collected. TREM-1 was available in 56 patients (33.9% male, mean age 43 yr); AA amyloidosis was associated in six patients (19.6% in FMF). Mean sTREM-1 level did not differ significantly between patients having an attack or not and there was also no significant correlation between the level of sTREM-1 and CRP and SAA protein. However, the mean rate of sTREM-1 was significantly higher among FMF patients with AA amyloidosis versus without, though the concomitant SAA protein level was normal. Serum level of sTREM-1 was higher in patients with amyloidosis even though the concomitant SAA protein level was normal. sTREM-1 plasma levels could be an accurate tool to specifically identify FMF patients with amyloidosis. |
| first_indexed | 2024-12-11T23:38:57Z |
| format | Article |
| id | doaj.art-9fa351fb36a54fd58b089271743fbef7 |
| institution | Directory Open Access Journal |
| issn | 1753-4259 1753-4267 |
| language | English |
| last_indexed | 2024-12-11T23:38:57Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Innate Immunity |
| spelling | doaj.art-9fa351fb36a54fd58b089271743fbef72022-12-22T00:45:48ZengSAGE PublishingInnate Immunity1753-42591753-42672019-11-012510.1177/1753425919870847In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosisClémence GorlierJérémie SellamLudivine LauransTabassome SimonIrina GiurgeaJean-Philippe BastardSoraya FellahiSamuel DeshayesGilles GrateauHafid Ait OufellaSophie Georgin-LavialleWe aimed to explore triggering receptor expressed on myeloid cells-1 (TREM-1) activation in familial Mediterranean fever (FMF), the most frequent monogenic auto-inflammatory disease, through the measurement of its serum soluble form, named sTREM-1. Blood samples from patients with FMF according to Livneh criteria followed in the French FMF national center and carrying two pathogenic MEFV mutations were collected. Serum level of sTREM-1 was assessed using ELISA. Demographic data, presence of FMF attack, association with histologically proven AA amyloidosis, and blood levels of C-reactive protein (CRP), serum amyloid A (SAA) protein, and creatinine were collected. TREM-1 was available in 56 patients (33.9% male, mean age 43 yr); AA amyloidosis was associated in six patients (19.6% in FMF). Mean sTREM-1 level did not differ significantly between patients having an attack or not and there was also no significant correlation between the level of sTREM-1 and CRP and SAA protein. However, the mean rate of sTREM-1 was significantly higher among FMF patients with AA amyloidosis versus without, though the concomitant SAA protein level was normal. Serum level of sTREM-1 was higher in patients with amyloidosis even though the concomitant SAA protein level was normal. sTREM-1 plasma levels could be an accurate tool to specifically identify FMF patients with amyloidosis.https://doi.org/10.1177/1753425919870847 |
| spellingShingle | Clémence Gorlier Jérémie Sellam Ludivine Laurans Tabassome Simon Irina Giurgea Jean-Philippe Bastard Soraya Fellahi Samuel Deshayes Gilles Grateau Hafid Ait Oufella Sophie Georgin-Lavialle In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis Innate Immunity |
| title | In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis |
| title_full | In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis |
| title_fullStr | In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis |
| title_full_unstemmed | In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis |
| title_short | In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis |
| title_sort | in familial mediterranean fever soluble trem 1 plasma level is higher in case of amyloidosis |
| url | https://doi.org/10.1177/1753425919870847 |
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