Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study
This study aimed to compare microbial species and multidrug resistance patterns in acute cholangitis patients with and without a history of cholecystectomy, highlighting potential differences We hypothesized that post-cholecystectomy patients would exhibit distinct microbial spectra and resistance p...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/12/1/19 |
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| author | Bogdan Miutescu Deiana Vuletici Calin Burciu Felix Bende Iulia Ratiu Tudor Moga Eyad Gadour Shruta Reddy Vasile Sandru Gheorghe Balan Greta Dancu Felix-Mihai Maralescu Alina Popescu |
| author_facet | Bogdan Miutescu Deiana Vuletici Calin Burciu Felix Bende Iulia Ratiu Tudor Moga Eyad Gadour Shruta Reddy Vasile Sandru Gheorghe Balan Greta Dancu Felix-Mihai Maralescu Alina Popescu |
| author_sort | Bogdan Miutescu |
| collection | DOAJ |
| description | This study aimed to compare microbial species and multidrug resistance patterns in acute cholangitis patients with and without a history of cholecystectomy, highlighting potential differences We hypothesized that post-cholecystectomy patients would exhibit distinct microbial spectra and resistance patterns. Conducted at a western Romanian hospital specializing in gastroenterology and hepatobiliary diseases from 2020 to 2023, this retrospective study included 488 acute cholangitis patients, divided into groups based on their cholecystectomy history. Bile and blood samples were analyzed for microbial identification and antibiotic susceptibility using VITEK<sup>®</sup>2. Positive biliary cultures were found in 66% of patients. The cholecystectomy group showed a higher prevalence of multidrug-resistant organisms, with 74.4% exhibiting resistance compared to 31.5% in the non-cholecystectomy group (<i>p</i> < 0.001). Notable microbial differences included higher occurrences of <i>Escherichia coli</i> (40.2%) and <i>Enterococcus</i> spp. (32.4%) in the cholecystectomy group. Resistance to Piperacillin/Tazobactam and Penems was significantly higher in this group, with odds ratios of 3.25 (<i>p</i> < 0.001) and 2.80 (<i>p</i> = 0.001), respectively, for the development of multidrug-resistant (MDR) bacterial species. The study confirmed our hypothesis, revealing distinct microbial profiles and a higher prevalence of multidrug resistance in acute cholangitis post-cholecystectomy patients. These findings underscore the need for tailored antibiotic strategies in managing acute cholangitis in this patient demographic. |
| first_indexed | 2024-03-08T11:00:21Z |
| format | Article |
| id | doaj.art-9fa45142d9e04738af9e28ea7bf6e0b2 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-08T11:00:21Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-9fa45142d9e04738af9e28ea7bf6e0b22024-01-26T16:03:37ZengMDPI AGDiseases2079-97212024-01-011211910.3390/diseases12010019Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center StudyBogdan Miutescu0Deiana Vuletici1Calin Burciu2Felix Bende3Iulia Ratiu4Tudor Moga5Eyad Gadour6Shruta Reddy7Vasile Sandru8Gheorghe Balan9Greta Dancu10Felix-Mihai Maralescu11Alina Popescu12Department of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology, King Abdulaziz Hospital-National Guard Health Affairs, Al Ahsa 31982, Saudi ArabiaDepartment of General Medicine, SVS Medical College, Yenugonda, Mahbubnagar 509001, Telangana, IndiaDepartment of Gastroenterology, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDivision of Nephrology, Department of Internal Medicine II, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaThis study aimed to compare microbial species and multidrug resistance patterns in acute cholangitis patients with and without a history of cholecystectomy, highlighting potential differences We hypothesized that post-cholecystectomy patients would exhibit distinct microbial spectra and resistance patterns. Conducted at a western Romanian hospital specializing in gastroenterology and hepatobiliary diseases from 2020 to 2023, this retrospective study included 488 acute cholangitis patients, divided into groups based on their cholecystectomy history. Bile and blood samples were analyzed for microbial identification and antibiotic susceptibility using VITEK<sup>®</sup>2. Positive biliary cultures were found in 66% of patients. The cholecystectomy group showed a higher prevalence of multidrug-resistant organisms, with 74.4% exhibiting resistance compared to 31.5% in the non-cholecystectomy group (<i>p</i> < 0.001). Notable microbial differences included higher occurrences of <i>Escherichia coli</i> (40.2%) and <i>Enterococcus</i> spp. (32.4%) in the cholecystectomy group. Resistance to Piperacillin/Tazobactam and Penems was significantly higher in this group, with odds ratios of 3.25 (<i>p</i> < 0.001) and 2.80 (<i>p</i> = 0.001), respectively, for the development of multidrug-resistant (MDR) bacterial species. The study confirmed our hypothesis, revealing distinct microbial profiles and a higher prevalence of multidrug resistance in acute cholangitis post-cholecystectomy patients. These findings underscore the need for tailored antibiotic strategies in managing acute cholangitis in this patient demographic.https://www.mdpi.com/2079-9721/12/1/19acute cholangitischolecystectomyantimicrobial resistance |
| spellingShingle | Bogdan Miutescu Deiana Vuletici Calin Burciu Felix Bende Iulia Ratiu Tudor Moga Eyad Gadour Shruta Reddy Vasile Sandru Gheorghe Balan Greta Dancu Felix-Mihai Maralescu Alina Popescu Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study Diseases acute cholangitis cholecystectomy antimicrobial resistance |
| title | Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study |
| title_full | Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study |
| title_fullStr | Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study |
| title_full_unstemmed | Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study |
| title_short | Comparative Analysis of Microbial Species and Multidrug Resistance Patterns in Acute Cholangitis Patients with Cholecystectomy: A Single-Center Study |
| title_sort | comparative analysis of microbial species and multidrug resistance patterns in acute cholangitis patients with cholecystectomy a single center study |
| topic | acute cholangitis cholecystectomy antimicrobial resistance |
| url | https://www.mdpi.com/2079-9721/12/1/19 |
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