HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?
Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation. Alzheimer’s disease (AD) is characterized by progressive synaptic dysf...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00307/full |
| _version_ | 1828435031191715840 |
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| author | Geoffrey Canet Chloé Dias Audrey Gabelle Yannick Simonin Fabien Gosselet Nicola Marchi Alain Makinson Edouard Tuaillon Edouard Tuaillon Philippe Van de Perre Philippe Van de Perre Laurent Givalois Sara Salinas |
| author_facet | Geoffrey Canet Chloé Dias Audrey Gabelle Yannick Simonin Fabien Gosselet Nicola Marchi Alain Makinson Edouard Tuaillon Edouard Tuaillon Philippe Van de Perre Philippe Van de Perre Laurent Givalois Sara Salinas |
| author_sort | Geoffrey Canet |
| collection | DOAJ |
| description | Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation. Alzheimer’s disease (AD) is characterized by progressive synaptic dysfunction and neurodegeneration that ultimately lead to dementia. Neuroinflammation also plays a prominent role in AD and possible links to viruses have been proposed. In particular, the human immunodeficiency virus (HIV) can pass the blood-brain barrier and cause neuronal dysfunction leading to cognitive dysfunctions called HIV-associated neurocognitive disorders (HAND). Similarities between HAND and HIV exist as numerous factors involved in AD such as members of the amyloid and Tau pathways, as well as stress-related pathways or blood brain barrier (BBB) regulators, seem to be modulated by HIV brain infection, leading to the accumulation of amyloid plaques or neurofibrillary tangles (NFT) in some patients. Here, we summarize findings regarding how HIV and some of its proteins such as Tat and gp120 modulate signaling and cellular pathways also impaired in AD, suggesting similarities and convergences of these two pathologies. |
| first_indexed | 2024-12-10T18:59:17Z |
| format | Article |
| id | doaj.art-9fa479a2c89c45b6b56bbe3857703357 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T18:59:17Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9fa479a2c89c45b6b56bbe38577033572022-12-22T01:37:02ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-09-011210.3389/fncel.2018.00307409397HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?Geoffrey Canet0Chloé Dias1Audrey Gabelle2Yannick Simonin3Fabien Gosselet4Nicola Marchi5Alain Makinson6Edouard Tuaillon7Edouard Tuaillon8Philippe Van de Perre9Philippe Van de Perre10Laurent Givalois11Sara Salinas12Molecular Mechanisms in Neurodegenerative Dementia, INSERM, University of Montpellier/EPHE, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, Montpellier, FranceMemory Research and Resources Center, CHU Montpellier, University of Montpellier, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, Montpellier, FranceLaboratoire de la Barrière Hémato-Encéphalique, Université d’Artois, Lens, FranceCerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics, CNRS, INSERM, University of Montpellier, Montpellier, FranceDepartment of Infectious Diseases CHU Montpellier, INSERM, IRD, University of Montpellier, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, CHU Montpellier, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, CHU Montpellier, Montpellier, FranceMolecular Mechanisms in Neurodegenerative Dementia, INSERM, University of Montpellier/EPHE, Montpellier, FrancePathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, Montpellier, FranceEnvironmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation. Alzheimer’s disease (AD) is characterized by progressive synaptic dysfunction and neurodegeneration that ultimately lead to dementia. Neuroinflammation also plays a prominent role in AD and possible links to viruses have been proposed. In particular, the human immunodeficiency virus (HIV) can pass the blood-brain barrier and cause neuronal dysfunction leading to cognitive dysfunctions called HIV-associated neurocognitive disorders (HAND). Similarities between HAND and HIV exist as numerous factors involved in AD such as members of the amyloid and Tau pathways, as well as stress-related pathways or blood brain barrier (BBB) regulators, seem to be modulated by HIV brain infection, leading to the accumulation of amyloid plaques or neurofibrillary tangles (NFT) in some patients. Here, we summarize findings regarding how HIV and some of its proteins such as Tat and gp120 modulate signaling and cellular pathways also impaired in AD, suggesting similarities and convergences of these two pathologies.https://www.frontiersin.org/article/10.3389/fncel.2018.00307/fullHIV-associated neurocognitive disordersneuroinflammationviral neuroinfectionAlzheimer’s diseasehypothalamo-pituitary-adrenal axis |
| spellingShingle | Geoffrey Canet Chloé Dias Audrey Gabelle Yannick Simonin Fabien Gosselet Nicola Marchi Alain Makinson Edouard Tuaillon Edouard Tuaillon Philippe Van de Perre Philippe Van de Perre Laurent Givalois Sara Salinas HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? Frontiers in Cellular Neuroscience HIV-associated neurocognitive disorders neuroinflammation viral neuroinfection Alzheimer’s disease hypothalamo-pituitary-adrenal axis |
| title | HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? |
| title_full | HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? |
| title_fullStr | HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? |
| title_full_unstemmed | HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? |
| title_short | HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links? |
| title_sort | hiv neuroinfection and alzheimer s disease similarities and potential links |
| topic | HIV-associated neurocognitive disorders neuroinflammation viral neuroinfection Alzheimer’s disease hypothalamo-pituitary-adrenal axis |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00307/full |
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