Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix
The potential of a mixture of glycosaminoglycans (GAGs) contained in an oral supplement for joint discomfort (OralviscTM) to prevent diet-induced obesity (DIO) and to serve as co-adjuvant in weight loss strategies was studied. Oral treatment with the GAG mix did not counteract the development of DIO...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616302171 |
| _version_ | 1818598303740198912 |
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| author | Bàrbara Reynés Alba Serrano Petar D. Petrov Joan Ribot Carles Chetrit Daniel Martínez-Puig M. Luisa Bonet Andreu Palou |
| author_facet | Bàrbara Reynés Alba Serrano Petar D. Petrov Joan Ribot Carles Chetrit Daniel Martínez-Puig M. Luisa Bonet Andreu Palou |
| author_sort | Bàrbara Reynés |
| collection | DOAJ |
| description | The potential of a mixture of glycosaminoglycans (GAGs) contained in an oral supplement for joint discomfort (OralviscTM) to prevent diet-induced obesity (DIO) and to serve as co-adjuvant in weight loss strategies was studied. Oral treatment with the GAG mix did not counteract the development of DIO in obesity-prone mice but reduced food intake under normal fat diet and led to increased insulin sensitivity under both normal and high fat diets. During reversal of DIO, GAG-treated obese mice showed higher and faster loss of body fat and displayed decreased endpoint adiposity, leptinaemia and hepatic steatosis and signs of increased insulin sensitivity compared with vehicle-treated controls. Expression of oxidative metabolism-related genes and mitochondrial DNA content were increased in visceral white fat depots of GAG-treated animals. The results sustain this GAG mix in functional foods/supplements for obesity and particularly for the (frequent) combination of obesity and joint dysfunction symptoms. |
| first_indexed | 2024-12-16T12:01:34Z |
| format | Article |
| id | doaj.art-9fa6b997039441749d3ccd9c862a65c8 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T12:01:34Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9fa6b997039441749d3ccd9c862a65c82022-12-21T22:32:27ZengElsevierJournal of Functional Foods1756-46462016-10-0126350362Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mixBàrbara Reynés0Alba Serrano1Petar D. Petrov2Joan Ribot3Carles Chetrit4Daniel Martínez-Puig5M. Luisa Bonet6Andreu Palou7Laboratory of Molecular Biology, Nutrition and Biotechnology – Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, SpainLaboratory of Molecular Biology, Nutrition and Biotechnology – Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, SpainLaboratory of Molecular Biology, Nutrition and Biotechnology – Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, SpainLaboratory of Molecular Biology, Nutrition and Biotechnology – Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, SpainBioiberica S.A., Palafolls, Barcelona, SpainBioiberica S.A., Palafolls, Barcelona, SpainLaboratory of Molecular Biology, Nutrition and Biotechnology – Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, Spain; Corresponding author. Edifici Mateu Orfila, Carretera de Valldemossa Km 7.5, 07122 Palma de Mallorca, Spain. Fax: +34 971173426.Laboratory of Molecular Biology, Nutrition and Biotechnology – Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, SpainThe potential of a mixture of glycosaminoglycans (GAGs) contained in an oral supplement for joint discomfort (OralviscTM) to prevent diet-induced obesity (DIO) and to serve as co-adjuvant in weight loss strategies was studied. Oral treatment with the GAG mix did not counteract the development of DIO in obesity-prone mice but reduced food intake under normal fat diet and led to increased insulin sensitivity under both normal and high fat diets. During reversal of DIO, GAG-treated obese mice showed higher and faster loss of body fat and displayed decreased endpoint adiposity, leptinaemia and hepatic steatosis and signs of increased insulin sensitivity compared with vehicle-treated controls. Expression of oxidative metabolism-related genes and mitochondrial DNA content were increased in visceral white fat depots of GAG-treated animals. The results sustain this GAG mix in functional foods/supplements for obesity and particularly for the (frequent) combination of obesity and joint dysfunction symptoms.http://www.sciencedirect.com/science/article/pii/S1756464616302171GlycosaminoglycansWeight lossFat lossWhite adipose tissueOxidative metabolism |
| spellingShingle | Bàrbara Reynés Alba Serrano Petar D. Petrov Joan Ribot Carles Chetrit Daniel Martínez-Puig M. Luisa Bonet Andreu Palou Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix Journal of Functional Foods Glycosaminoglycans Weight loss Fat loss White adipose tissue Oxidative metabolism |
| title | Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix |
| title_full | Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix |
| title_fullStr | Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix |
| title_full_unstemmed | Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix |
| title_short | Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix |
| title_sort | anti obesity and insulin sensitising effects of a glycosaminoglycan mix |
| topic | Glycosaminoglycans Weight loss Fat loss White adipose tissue Oxidative metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616302171 |
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