Unravelling and engineering an operon involved in the side-chain degradation of sterols in Mycolicibacterium neoaurum for the production of steroid synthons

Unravelling and engineering an operon involved in the side-chain degradation of sterols in Mycolicibacterium neoaurum for the production of steroid synthons

Abstract Background Harnessing engineered Mycolicibacteria to convert cheap phytosterols into valuable steroid synthons is a basic way in the industry for the production of steroid hormones. Thus, C-19 and C-22 steroids are the two main types of commercial synthons and the products of C17 side chain...

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Bibliographic Details
Main Authors: Yun-Qiu Zhao, Yong-Jun Liu, Lu Song, Dingyan Yu, Kun Liu, Ke Liu, Bei Gao, Xin-Yi Tao, Liang-Bin Xiong, Feng-Qing Wang, Dong-Zhi Wei
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
Mycolicibacteria
HBC sub-pathway
atf1
HBC operon
C-22 steroid
4-HBC
Online Access:https://doi.org/10.1186/s13068-023-02376-2

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