Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia
Background Paediatric community-acquired pneumonia (CAP) is a leading cause of paediatric morbidity. However, particularly for outpatients with paediatric CAP, data on aetiology and management are scarce. Methods The prospective pedCAPNETZ study multicentrically enrols children and adolescents with...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2023-03-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/9/2/00286-2022.full |
| _version_ | 1797809384343994368 |
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| author | Martin Wetzke Katharina Schütz Matthias Volkmar Kopp Jürgen Seidenberg Christian Vogelberg Tobias Ankermann Christine Happle Gesche Voigt Holger Köster Thomas Illig Christiane Lex Antje Schuster Ralph Maier Marcus Panning Grit Barten Gernot Rohde Tobias Welte Gesine Hansen |
| author_facet | Martin Wetzke Katharina Schütz Matthias Volkmar Kopp Jürgen Seidenberg Christian Vogelberg Tobias Ankermann Christine Happle Gesche Voigt Holger Köster Thomas Illig Christiane Lex Antje Schuster Ralph Maier Marcus Panning Grit Barten Gernot Rohde Tobias Welte Gesine Hansen |
| author_sort | Martin Wetzke |
| collection | DOAJ |
| description | Background
Paediatric community-acquired pneumonia (CAP) is a leading cause of paediatric morbidity. However, particularly for outpatients with paediatric CAP, data on aetiology and management are scarce.
Methods
The prospective pedCAPNETZ study multicentrically enrols children and adolescents with outpatient-treated or hospitalised paediatric CAP in Germany. Blood and respiratory specimens were collected systematically, and comprehensive analyses of pathogen spectra were conducted. Follow-up evaluations were performed until day 90 after enrolment.
Results
Between December 2014 and August 2020, we enrolled 486 children with paediatric CAP at eight study sites, 437 (89.9%) of whom had radiographic evidence of paediatric CAP. Median (interquartile range) age was 4.5 (1.6–6.6) years, and 345 (78.9%) children were hospitalised. The most prevalent symptoms at enrolment were cough (91.8%), fever (89.2%) and tachypnoea (62.0%). Outpatients were significantly older, displayed significantly lower C-reactive protein levels and were significantly more likely to be symptom-free at follow-up days 14 and 90. Pathogens were detected in 90.3% of all patients (one or more viral pathogens in 68.1%; one or more bacterial strains in 18.7%; combined bacterial/viral pathogens in 4.1%). Parainfluenza virus and Mycoplasma pneumoniae were significantly more frequent in outpatients. The proportion of patients with antibiotic therapy was comparably high in both groups (92.4% of outpatients versus 86.2% of hospitalised patients).
Conclusion
We present first data on paediatric CAP with comprehensive analyses in outpatients and hospitalised cases and demonstrate high detection rates of viral pathogens in both groups. Particularly in young paediatric CAP patients with outpatient care, antibiotic therapy needs to be critically debated. |
| first_indexed | 2024-03-13T06:51:51Z |
| format | Article |
| id | doaj.art-9fa7d83f75914a4f84d8717ae3504d9b |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:51:51Z |
| publishDate | 2023-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-9fa7d83f75914a4f84d8717ae3504d9b2023-06-07T13:31:07ZengEuropean Respiratory SocietyERJ Open Research2312-05412023-03-019210.1183/23120541.00286-202200286-2022Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumoniaMartin Wetzke0Katharina Schütz1Matthias Volkmar Kopp2Jürgen Seidenberg3Christian Vogelberg4Tobias Ankermann5Christine Happle6Gesche Voigt7Holger Köster8Thomas Illig9Christiane Lex10Antje Schuster11Ralph Maier12Marcus Panning13Grit Barten14Gernot Rohde15Tobias Welte16Gesine Hansen17 Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany Biomedical Research in End stage and Obstructive Lung Disease (BREATH) Hannover and Airway Research Center North (ARCN) Lübeck, Member of the German Center for Lung Research (DZL), Lübeck, Germany Department of Paediatric Pneumology and Allergology, Universitätsklinik für Kinder- und Jugendmedizin Oldenburg, Oldenburg, Germany University Children's Hospital, Technical University Dresden, Dresden, Germany Department of Paediatric Pulmonology, Clinic of Pediatrics UKSH, University of Kiel, Kiel, Germany Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany Department of Paediatric Allergy and Pulmonology, Clinic of Pediatrics UKSH, University of Luebeck, Lübeck, Germany Department of Paediatric Pneumology and Allergology, Universitätsklinik für Kinder- und Jugendmedizin Oldenburg, Oldenburg, Germany Biomedical Research in End stage and Obstructive Lung Disease (BREATH) Hannover and Airway Research Center North (ARCN) Lübeck, Member of the German Center for Lung Research (DZL), Lübeck, Germany Department of Paediatric Pulmonology, University of Göttingen, Göttingen, Germany Department of Paediatrics, University of Düsseldorf, Düsseldorf, Germany Private Practice for Children, Tuttlingen, Germany Institute of Virology, University of Freiburg, Freiburg, Germany Biomedical Research in End stage and Obstructive Lung Disease (BREATH) Hannover and Airway Research Center North (ARCN) Lübeck, Member of the German Center for Lung Research (DZL), Lübeck, Germany CAPNETZ STIFTUNG, Hannover, Germany Biomedical Research in End stage and Obstructive Lung Disease (BREATH) Hannover and Airway Research Center North (ARCN) Lübeck, Member of the German Center for Lung Research (DZL), Lübeck, Germany Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany Background Paediatric community-acquired pneumonia (CAP) is a leading cause of paediatric morbidity. However, particularly for outpatients with paediatric CAP, data on aetiology and management are scarce. Methods The prospective pedCAPNETZ study multicentrically enrols children and adolescents with outpatient-treated or hospitalised paediatric CAP in Germany. Blood and respiratory specimens were collected systematically, and comprehensive analyses of pathogen spectra were conducted. Follow-up evaluations were performed until day 90 after enrolment. Results Between December 2014 and August 2020, we enrolled 486 children with paediatric CAP at eight study sites, 437 (89.9%) of whom had radiographic evidence of paediatric CAP. Median (interquartile range) age was 4.5 (1.6–6.6) years, and 345 (78.9%) children were hospitalised. The most prevalent symptoms at enrolment were cough (91.8%), fever (89.2%) and tachypnoea (62.0%). Outpatients were significantly older, displayed significantly lower C-reactive protein levels and were significantly more likely to be symptom-free at follow-up days 14 and 90. Pathogens were detected in 90.3% of all patients (one or more viral pathogens in 68.1%; one or more bacterial strains in 18.7%; combined bacterial/viral pathogens in 4.1%). Parainfluenza virus and Mycoplasma pneumoniae were significantly more frequent in outpatients. The proportion of patients with antibiotic therapy was comparably high in both groups (92.4% of outpatients versus 86.2% of hospitalised patients). Conclusion We present first data on paediatric CAP with comprehensive analyses in outpatients and hospitalised cases and demonstrate high detection rates of viral pathogens in both groups. Particularly in young paediatric CAP patients with outpatient care, antibiotic therapy needs to be critically debated.http://openres.ersjournals.com/content/9/2/00286-2022.full |
| spellingShingle | Martin Wetzke Katharina Schütz Matthias Volkmar Kopp Jürgen Seidenberg Christian Vogelberg Tobias Ankermann Christine Happle Gesche Voigt Holger Köster Thomas Illig Christiane Lex Antje Schuster Ralph Maier Marcus Panning Grit Barten Gernot Rohde Tobias Welte Gesine Hansen Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia ERJ Open Research |
| title | Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia |
| title_full | Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia |
| title_fullStr | Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia |
| title_full_unstemmed | Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia |
| title_short | Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia |
| title_sort | pathogen spectra in hospitalised and nonhospitalised children with community acquired pneumonia |
| url | http://openres.ersjournals.com/content/9/2/00286-2022.full |
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