Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition?
Abstract Purpose To assess whether the high metabolic region of fluorine-18-fluorode-oxyglucose (18F-FDG) in the primary lesion is the crux for recurrence in patients with nasopharyngeal carcinoma (NPC), to assess the feasibility and rationale for use of biological target volume (BTV) based on 18F-F...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-02-01
|
| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-023-02225-4 |
| _version_ | 1797863961222184960 |
|---|---|
| author | Ting Xu Ye Feng Huiling Hong Yiying Xu Jiawei Chen Xiufang Qiu Jianming Ding Chaoxiong Huang Li Li Chuanben Chen Zhaodong Fei |
| author_facet | Ting Xu Ye Feng Huiling Hong Yiying Xu Jiawei Chen Xiufang Qiu Jianming Ding Chaoxiong Huang Li Li Chuanben Chen Zhaodong Fei |
| author_sort | Ting Xu |
| collection | DOAJ |
| description | Abstract Purpose To assess whether the high metabolic region of fluorine-18-fluorode-oxyglucose (18F-FDG) in the primary lesion is the crux for recurrence in patients with nasopharyngeal carcinoma (NPC), to assess the feasibility and rationale for use of biological target volume (BTV) based on 18F-FDG positron emission tomography/computed tomography (18F-FDG-PET/CT). Methods The retrospective study included 33 patients with NPC who underwent 18F-FDG-PET/CT at the time of initial diagnosis as well as the time of diagnosis of local recurrence. Paired 18F-FDG-PET/CT images for primary and recurrent lesion were matched by deformation coregistration method to determine the cross-failure rate between two lesions. Results The median volume of the Vpri (primary tumor volume using the SUV thresholds of 2.5), the Vhigh (the volume of high FDG uptake using the SUV50%max isocontour), and the Vrecur (the recurrent tumor volume using the SUV thresholds of 2.5) were 22.85, 5.57, and 9.98 cm3, respectively. The cross-failure rate of Vrecur∩high showed that 82.82% (27/33) of local recurrent lesions had < 50% overlap volume with the region of high FDG uptake. The cross-failure rate of Vrecur∩pri showed that 96.97% (32/33) of local recurrent lesions had > 20% overlap volume with the primary tumor lesions and the median cross rate was up to 71.74%. Conclusion 18F-FDG-PET/CT may be a powerful tool for automatic target volume delineation, but it may not be the optimal imaging modality for dose escalation radiotherapy based on applicable isocontour. The combination of other functional imaging could delineate the BTV more accurately. |
| first_indexed | 2024-04-09T22:44:00Z |
| format | Article |
| id | doaj.art-9fa8aea5f4924cf686dd952c9c95d45b |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-09T22:44:00Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-9fa8aea5f4924cf686dd952c9c95d45b2023-03-22T11:58:23ZengBMCRadiation Oncology1748-717X2023-02-0118111010.1186/s13014-023-02225-4Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition?Ting Xu0Ye Feng1Huiling Hong2Yiying Xu3Jiawei Chen4Xiufang Qiu5Jianming Ding6Chaoxiong Huang7Li Li8Chuanben Chen9Zhaodong Fei10Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalAbstract Purpose To assess whether the high metabolic region of fluorine-18-fluorode-oxyglucose (18F-FDG) in the primary lesion is the crux for recurrence in patients with nasopharyngeal carcinoma (NPC), to assess the feasibility and rationale for use of biological target volume (BTV) based on 18F-FDG positron emission tomography/computed tomography (18F-FDG-PET/CT). Methods The retrospective study included 33 patients with NPC who underwent 18F-FDG-PET/CT at the time of initial diagnosis as well as the time of diagnosis of local recurrence. Paired 18F-FDG-PET/CT images for primary and recurrent lesion were matched by deformation coregistration method to determine the cross-failure rate between two lesions. Results The median volume of the Vpri (primary tumor volume using the SUV thresholds of 2.5), the Vhigh (the volume of high FDG uptake using the SUV50%max isocontour), and the Vrecur (the recurrent tumor volume using the SUV thresholds of 2.5) were 22.85, 5.57, and 9.98 cm3, respectively. The cross-failure rate of Vrecur∩high showed that 82.82% (27/33) of local recurrent lesions had < 50% overlap volume with the region of high FDG uptake. The cross-failure rate of Vrecur∩pri showed that 96.97% (32/33) of local recurrent lesions had > 20% overlap volume with the primary tumor lesions and the median cross rate was up to 71.74%. Conclusion 18F-FDG-PET/CT may be a powerful tool for automatic target volume delineation, but it may not be the optimal imaging modality for dose escalation radiotherapy based on applicable isocontour. The combination of other functional imaging could delineate the BTV more accurately.https://doi.org/10.1186/s13014-023-02225-4Nasopharyngeal carcinoma18F-FDG-PET/CTBiological target volumeLocal recurrenceStandardized uptake value |
| spellingShingle | Ting Xu Ye Feng Huiling Hong Yiying Xu Jiawei Chen Xiufang Qiu Jianming Ding Chaoxiong Huang Li Li Chuanben Chen Zhaodong Fei Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? Radiation Oncology Nasopharyngeal carcinoma 18F-FDG-PET/CT Biological target volume Local recurrence Standardized uptake value |
| title | Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? |
| title_full | Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? |
| title_fullStr | Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? |
| title_full_unstemmed | Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? |
| title_short | Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? |
| title_sort | biological target volume based on fluorine 18 fluorode oxyglucose positron emission tomography computed tomography imaging a spurious proposition |
| topic | Nasopharyngeal carcinoma 18F-FDG-PET/CT Biological target volume Local recurrence Standardized uptake value |
| url | https://doi.org/10.1186/s13014-023-02225-4 |
| work_keys_str_mv | AT tingxu biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT yefeng biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT huilinghong biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT yiyingxu biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT jiaweichen biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT xiufangqiu biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT jianmingding biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT chaoxionghuang biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT lili biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT chuanbenchen biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition AT zhaodongfei biologicaltargetvolumebasedonfluorine18fluorodeoxyglucosepositronemissiontomographycomputedtomographyimagingaspuriousproposition |