Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption
PurposeTo describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 therapy and drugs known to interfere with L-T4 absorption.MethodsA PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies and reviews written in Eng...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1080108/full |
| _version_ | 1811212828080603136 |
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| author | Elisa Gatta Francesca Bambini Caterina Buoso Maria Gava Virginia Maltese Valentina Anelli Andrea Delbarba Ilenia Pirola Carlo Cappelli |
| author_facet | Elisa Gatta Francesca Bambini Caterina Buoso Maria Gava Virginia Maltese Valentina Anelli Andrea Delbarba Ilenia Pirola Carlo Cappelli |
| author_sort | Elisa Gatta |
| collection | DOAJ |
| description | PurposeTo describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 therapy and drugs known to interfere with L-T4 absorption.MethodsA PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies and reviews written in English and published online up to 31 August 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.ResultsThe available data showed that novel levothyroxine formulations circumvent gastric pH impairment due to multiple interfering drugs such as proton pump inhibitors, calcium or iron supplements, sevelamer, aluminum/magnesium hydroxide and sodium alginate.ConclusionNew formulations can be taken simultaneously with drugs interfering with L-T4 absorption, in particular liquid formulations. Softgel capsules need more studies to support these data. |
| first_indexed | 2024-04-12T05:35:50Z |
| format | Article |
| id | doaj.art-9fa8b8d33b034421a9bce6f3a7aa1c1e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T05:35:50Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9fa8b8d33b034421a9bce6f3a7aa1c1e2022-12-22T03:45:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10801081080108Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorptionElisa GattaFrancesca BambiniCaterina BuosoMaria GavaVirginia MalteseValentina AnelliAndrea DelbarbaIlenia PirolaCarlo CappelliPurposeTo describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 therapy and drugs known to interfere with L-T4 absorption.MethodsA PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies and reviews written in English and published online up to 31 August 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.ResultsThe available data showed that novel levothyroxine formulations circumvent gastric pH impairment due to multiple interfering drugs such as proton pump inhibitors, calcium or iron supplements, sevelamer, aluminum/magnesium hydroxide and sodium alginate.ConclusionNew formulations can be taken simultaneously with drugs interfering with L-T4 absorption, in particular liquid formulations. Softgel capsules need more studies to support these data.https://www.frontiersin.org/articles/10.3389/fendo.2022.1080108/fulllevothyroxineliquid levothyroxinesoftgel capsulesinterfering drugslevothyroxine malabsorption |
| spellingShingle | Elisa Gatta Francesca Bambini Caterina Buoso Maria Gava Virginia Maltese Valentina Anelli Andrea Delbarba Ilenia Pirola Carlo Cappelli Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption Frontiers in Endocrinology levothyroxine liquid levothyroxine softgel capsules interfering drugs levothyroxine malabsorption |
| title | Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption |
| title_full | Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption |
| title_fullStr | Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption |
| title_full_unstemmed | Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption |
| title_short | Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption |
| title_sort | liquid levothyroxine formulations in patients taking drugs interfering with l t4 absorption |
| topic | levothyroxine liquid levothyroxine softgel capsules interfering drugs levothyroxine malabsorption |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1080108/full |
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