Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

<b>Background</b>: Dominant mutations in <i>COL3A1</i> are known to cause vascular Ehlers–Danlos syndrome (vEDS) by impairing extracellular matrix (ECM) homeostasis. This disruption leads to the fragility of soft connective tissues and a significantly increased risk of life-t...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Nicola Chiarelli, Valeria Cinquina, Nicoletta Zoppi, Valeria Bertini, Marianna Maddaluno, Chiara De Leonibus, Carmine Settembre, Marina Venturini, Marina Colombi, Marco Ritelli
التنسيق:	مقال
اللغة:	English
منشور في:	MDPI AG 2024-11-01
سلاسل:	Biomedicines
الموضوعات:	extracellular matrix collagen type I collagen type V miR-29b multi-omics approach proteome
الوصول للمادة أونلاين:	https://www.mdpi.com/2227-9059/12/12/2749

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