Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

<b>Background</b>: Dominant mutations in <i>COL3A1</i> are known to cause vascular Ehlers–Danlos syndrome (vEDS) by impairing extracellular matrix (ECM) homeostasis. This disruption leads to the fragility of soft connective tissues and a significantly increased risk of life-t...

Descripció completa

Dades bibliogràfiques
Autors principals:	Nicola Chiarelli, Valeria Cinquina, Nicoletta Zoppi, Valeria Bertini, Marianna Maddaluno, Chiara De Leonibus, Carmine Settembre, Marina Venturini, Marina Colombi, Marco Ritelli
Format:	Article
Idioma:	English
Publicat:	MDPI AG 2024-11-01
Col·lecció:	Biomedicines
Matèries:	extracellular matrix collagen type I collagen type V miR-29b multi-omics approach proteome
Accés en línia:	https://www.mdpi.com/2227-9059/12/12/2749

Ítems similars

RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms
per: Marco Ritelli, et al.
Publicat: (2022-12-01)

Multisystemic manifestations in a cohort of 75 classical Ehlers-Danlos syndrome patients: natural history and nosological perspectives
per: Marco Ritelli, et al.
Publicat: (2020-07-01)

Expanding the clinical and mutational spectrum of B4GALT7-spondylodysplastic Ehlers-Danlos syndrome
per: Marco Ritelli, et al.
Publicat: (2017-09-01)

Matrix Metalloproteinases Inhibition by Doxycycline Rescues Extracellular Matrix Organization and Partly Reverts Myofibroblast Differentiation in Hypermobile Ehlers-Danlos Syndrome Dermal Fibroblasts: A Potential Therapeutic Target?
per: Nicola Chiarelli, et al.
Publicat: (2021-11-01)

Ehlers-Danlos syndrome in a crossbreed cat
per: Silvana Marques Caramalac, et al.
Publicat: (2022-04-01)

Identification of the novel COL5A1 c.3369_3431dup, p.(Glu1124_Gly1144dup) variant in a patient with incomplete classical Ehlers–Danlos syndrome: The importance of phenotype‐guided genetic testing
per: Marco Ritelli, et al.
Publicat: (2020-10-01)

Prepubertal Periodontitis in a Patient with Combined Classical and Periodontal Ehlers–Danlos Syndrome
per: Friedrich Stock, et al.
Publicat: (2021-01-01)

Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients' skin fibroblasts.
per: Nicola Chiarelli, et al.
Publicat: (2019-01-01)

Ehler-Danlos syndrome (Case report)
per: B.Soltani (M.D), et al.
Publicat: (2003-03-01)

Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type.
per: Nicola Chiarelli, et al.
Publicat: (2016-01-01)

Ehlers Danlos Syndrome – A Case Report
per: Pragati Kaurani, et al.
Publicat: (2014-03-01)

Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome.
per: Nicola Chiarelli, et al.
Publicat: (2018-01-01)

Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts
per: Linda Yulianti, et al.
Publicat: (2015-08-01)

Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts
per: Linda Yuliati, et al.
Publicat: (2015-12-01)

Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture
per: Ana Sanchez, et al.
Publicat: (2018-04-01)

Dermal type I collagen assessment by digital image analysis
per: Gabrielli Brianezi, et al.
Publicat: (2015-10-01)

Ocular Motility Abnormalities in Ehlers-Danlos Syndrome: An Observational Study
per: Anna Maria Comberiati, et al.
Publicat: (2023-04-01)

Mechanobiology in the Comorbidities of Ehlers Danlos Syndrome
per: Shaina P. Royer, et al.
Publicat: (2022-04-01)

Editorial: Ehlers-Danlos syndrome: from bedside to bench
per: Tomoki Kosho, et al.
Publicat: (2024-04-01)

Multi‐exon COL5A1 deletion in a child with classical Ehlers–Danlos syndrome: A case report expanding the allelic spectrum and showing evidence of parental gonosomal mosaicism
per: Sonja Strang‐Karlsson, et al.
Publicat: (2022-10-01)

COLLAGEN: STRUCTURE, METABOLISM, PRODUCTION AND INDUSTRIAL APPLICATION
per: A. K. Gulevsky, et al.
Publicat: (2020-10-01)

Collagen fibril formation in vitro: From origin to opportunities
per: Diana M. Darvish
Publicat: (2022-06-01)

Clinical features and morphology of collagen fibrils in patients with vascular Ehlers–Danlos based on electron microscopy
per: Satoko Ishikawa, et al.
Publicat: (2023-08-01)

Isolation and Characterisation of Major and Minor Collagens from Hyaline Cartilage of Hoki (<em>Macruronus</em> <em>novaezelandiae</em>)
per: Mathew H. Cumming, et al.
Publicat: (2019-04-01)

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process
per: CARLOS AUGUSTO NUNES MARTINI, et al.

A Heterozygous Missense Variant in the <i>COL5A2</i> in Holstein Cattle Resembling the Classical Ehlers–Danlos Syndrome
per: Joana G. P. Jacinto, et al.
Publicat: (2020-10-01)

Classical Ehlers-Danlos syndrome: clinical, Histological and ultrastructural aspects Síndrome de Ehlers-Danlos clássica: aspectos clínicos, histológicos e ultraestruturais
per: Eduardo de Barros Coelho Bicca, et al.
Publicat: (2011-08-01)

Lack of autoantibodies against collagen and related proteins in collagenous colitis
per: Larsson JK, et al.
Publicat: (2022-06-01)

Next-Generation Sequencing of Connective Tissue Genes in Patients with Classical Ehlers-Danlos Syndrome
per: Anna Junkiert-Czarnecka, et al.
Publicat: (2022-03-01)

Hidradenitis suppurativa and Ehlers-Danlos syndrome: A case-control study
per: Vivian J. Hua, MD, et al.
Publicat: (2023-09-01)

Morphometric analysis of the human endoneurial extracellular matrix components during aging
per: Kundalić Braca K., et al.
Publicat: (2021-01-01)

Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome
per: Albert Amberger, et al.
Publicat: (2023-03-01)

Isolation and Characterization of Collagen and Collagen Peptides with Hyaluronidase Inhibition Activity Derived from the Skin of Marlin (<i>Istiophoridae</i>)
per: Qiu-Yu Han, et al.
Publicat: (2023-01-01)

MicroRNA-21 and microRNA-29a modulate the expression of collagen in dermal fibroblasts of patients with systemic sclerosis
per: Saeideh Jafarinejad-Farsangi, et al.
Publicat: (2019-04-01)

Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (<i>Lagenodelphis hosei</i>)
per: Chen-Yi Su, et al.
Publicat: (2023-05-01)

Aging and the Impact of Solar Ultraviolet Radiation on the Expression of Type I and Type VI Collagen
per: Foteini Biskanaki, et al.
Publicat: (2023-03-01)

Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues
per: Yihui Song, et al.
Publicat: (2021-08-01)

The vascular type of Ehlers–Danlos syndrome
per: Maria V. Gubanova, et al.
Publicat: (2017-02-01)

Non-invasive ultrasound-based assessment of ventricular–arterial interaction in vascular Ehlers–Danlos syndrome patients
per: Koen D. Reesink, et al.
Publicat: (2010-12-01)

Ballooning and Bursting of Barrels and Pipes: A Rare Case of Suspected Vascular Ehlers–Danlos Disease
per: Ogechi Agogbuo, et al.
Publicat: (2024-11-01)