Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

<b>Background</b>: Dominant mutations in <i>COL3A1</i> are known to cause vascular Ehlers–Danlos syndrome (vEDS) by impairing extracellular matrix (ECM) homeostasis. This disruption leads to the fragility of soft connective tissues and a significantly increased risk of life-t...

Podrobná bibliografie
Hlavní autoři:	Nicola Chiarelli, Valeria Cinquina, Nicoletta Zoppi, Valeria Bertini, Marianna Maddaluno, Chiara De Leonibus, Carmine Settembre, Marina Venturini, Marina Colombi, Marco Ritelli
Médium:	Článek
Jazyk:	English
Vydáno:	MDPI AG 2024-11-01
Edice:	Biomedicines
Témata:	extracellular matrix collagen type I collagen type V miR-29b multi-omics approach proteome
On-line přístup:	https://www.mdpi.com/2227-9059/12/12/2749

Podobné jednotky

RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms
Autor: Marco Ritelli, a další
Vydáno: (2022-12-01)

Multisystemic manifestations in a cohort of 75 classical Ehlers-Danlos syndrome patients: natural history and nosological perspectives
Autor: Marco Ritelli, a další
Vydáno: (2020-07-01)

Expanding the clinical and mutational spectrum of B4GALT7-spondylodysplastic Ehlers-Danlos syndrome
Autor: Marco Ritelli, a další
Vydáno: (2017-09-01)

Matrix Metalloproteinases Inhibition by Doxycycline Rescues Extracellular Matrix Organization and Partly Reverts Myofibroblast Differentiation in Hypermobile Ehlers-Danlos Syndrome Dermal Fibroblasts: A Potential Therapeutic Target?
Autor: Nicola Chiarelli, a další
Vydáno: (2021-11-01)

Ehlers-Danlos syndrome in a crossbreed cat
Autor: Silvana Marques Caramalac, a další
Vydáno: (2022-04-01)

Identification of the novel COL5A1 c.3369_3431dup, p.(Glu1124_Gly1144dup) variant in a patient with incomplete classical Ehlers–Danlos syndrome: The importance of phenotype‐guided genetic testing
Autor: Marco Ritelli, a další
Vydáno: (2020-10-01)

Prepubertal Periodontitis in a Patient with Combined Classical and Periodontal Ehlers–Danlos Syndrome
Autor: Friedrich Stock, a další
Vydáno: (2021-01-01)

Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients' skin fibroblasts.
Autor: Nicola Chiarelli, a další
Vydáno: (2019-01-01)

Ehler-Danlos syndrome (Case report)
Autor: B.Soltani (M.D), a další
Vydáno: (2003-03-01)

Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type.
Autor: Nicola Chiarelli, a další
Vydáno: (2016-01-01)

Ehlers Danlos Syndrome – A Case Report
Autor: Pragati Kaurani, a další
Vydáno: (2014-03-01)

Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome.
Autor: Nicola Chiarelli, a další
Vydáno: (2018-01-01)

Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts
Autor: Linda Yulianti, a další
Vydáno: (2015-08-01)

Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts
Autor: Linda Yuliati, a další
Vydáno: (2015-12-01)

Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture
Autor: Ana Sanchez, a další
Vydáno: (2018-04-01)

Dermal type I collagen assessment by digital image analysis
Autor: Gabrielli Brianezi, a další
Vydáno: (2015-10-01)

Ocular Motility Abnormalities in Ehlers-Danlos Syndrome: An Observational Study
Autor: Anna Maria Comberiati, a další
Vydáno: (2023-04-01)

Mechanobiology in the Comorbidities of Ehlers Danlos Syndrome
Autor: Shaina P. Royer, a další
Vydáno: (2022-04-01)

Editorial: Ehlers-Danlos syndrome: from bedside to bench
Autor: Tomoki Kosho, a další
Vydáno: (2024-04-01)

Multi‐exon COL5A1 deletion in a child with classical Ehlers–Danlos syndrome: A case report expanding the allelic spectrum and showing evidence of parental gonosomal mosaicism
Autor: Sonja Strang‐Karlsson, a další
Vydáno: (2022-10-01)

COLLAGEN: STRUCTURE, METABOLISM, PRODUCTION AND INDUSTRIAL APPLICATION
Autor: A. K. Gulevsky, a další
Vydáno: (2020-10-01)

Collagen fibril formation in vitro: From origin to opportunities
Autor: Diana M. Darvish
Vydáno: (2022-06-01)

Clinical features and morphology of collagen fibrils in patients with vascular Ehlers–Danlos based on electron microscopy
Autor: Satoko Ishikawa, a další
Vydáno: (2023-08-01)

Isolation and Characterisation of Major and Minor Collagens from Hyaline Cartilage of Hoki (<em>Macruronus</em> <em>novaezelandiae</em>)
Autor: Mathew H. Cumming, a další
Vydáno: (2019-04-01)

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process
Autor: CARLOS AUGUSTO NUNES MARTINI, a další

A Heterozygous Missense Variant in the <i>COL5A2</i> in Holstein Cattle Resembling the Classical Ehlers–Danlos Syndrome
Autor: Joana G. P. Jacinto, a další
Vydáno: (2020-10-01)

Classical Ehlers-Danlos syndrome: clinical, Histological and ultrastructural aspects Síndrome de Ehlers-Danlos clássica: aspectos clínicos, histológicos e ultraestruturais
Autor: Eduardo de Barros Coelho Bicca, a další
Vydáno: (2011-08-01)

Lack of autoantibodies against collagen and related proteins in collagenous colitis
Autor: Larsson JK, a další
Vydáno: (2022-06-01)

Next-Generation Sequencing of Connective Tissue Genes in Patients with Classical Ehlers-Danlos Syndrome
Autor: Anna Junkiert-Czarnecka, a další
Vydáno: (2022-03-01)

Hidradenitis suppurativa and Ehlers-Danlos syndrome: A case-control study
Autor: Vivian J. Hua, MD, a další
Vydáno: (2023-09-01)

Morphometric analysis of the human endoneurial extracellular matrix components during aging
Autor: Kundalić Braca K., a další
Vydáno: (2021-01-01)

Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome
Autor: Albert Amberger, a další
Vydáno: (2023-03-01)

Isolation and Characterization of Collagen and Collagen Peptides with Hyaluronidase Inhibition Activity Derived from the Skin of Marlin (<i>Istiophoridae</i>)
Autor: Qiu-Yu Han, a další
Vydáno: (2023-01-01)

MicroRNA-21 and microRNA-29a modulate the expression of collagen in dermal fibroblasts of patients with systemic sclerosis
Autor: Saeideh Jafarinejad-Farsangi, a další
Vydáno: (2019-04-01)

Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (<i>Lagenodelphis hosei</i>)
Autor: Chen-Yi Su, a další
Vydáno: (2023-05-01)

Aging and the Impact of Solar Ultraviolet Radiation on the Expression of Type I and Type VI Collagen
Autor: Foteini Biskanaki, a další
Vydáno: (2023-03-01)

Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues
Autor: Yihui Song, a další
Vydáno: (2021-08-01)

The vascular type of Ehlers–Danlos syndrome
Autor: Maria V. Gubanova, a další
Vydáno: (2017-02-01)

Non-invasive ultrasound-based assessment of ventricular–arterial interaction in vascular Ehlers–Danlos syndrome patients
Autor: Koen D. Reesink, a další
Vydáno: (2010-12-01)

Ballooning and Bursting of Barrels and Pipes: A Rare Case of Suspected Vascular Ehlers–Danlos Disease
Autor: Ogechi Agogbuo, a další
Vydáno: (2024-11-01)