Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

Integrative Multi-Omics Approach in Vascular Ehlers–Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal Fibroblasts

<b>Background</b>: Dominant mutations in <i>COL3A1</i> are known to cause vascular Ehlers–Danlos syndrome (vEDS) by impairing extracellular matrix (ECM) homeostasis. This disruption leads to the fragility of soft connective tissues and a significantly increased risk of life-t...

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Hlavní autoři: Nicola Chiarelli, Valeria Cinquina, Nicoletta Zoppi, Valeria Bertini, Marianna Maddaluno, Chiara De Leonibus, Carmine Settembre, Marina Venturini, Marina Colombi, Marco Ritelli
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2024-11-01
Edice:Biomedicines
Témata:
extracellular matrix
collagen type I
collagen type V
miR-29b
multi-omics approach
proteome
On-line přístup:https://www.mdpi.com/2227-9059/12/12/2749

Internet

https://www.mdpi.com/2227-9059/12/12/2749

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