Detection of a weaker subgroup of A in ABO blood group system
Testing to detect ABO incompatibility between a donor and potential transfusion recipient is the foundation on which all other pretransfusion testing is based. Sometimes, weak agglutination reactions may be obtained with reagent antibodies due to weak expression of A and B antigens on red blood cell...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=132;epage=134;aulast= |
| _version_ | 1811313245393256448 |
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| author | Gurika Chopra Manpreet Kataria Arshpreet Kaur Batra Gurkiran kaur Rajesh Kumar |
| author_facet | Gurika Chopra Manpreet Kataria Arshpreet Kaur Batra Gurkiran kaur Rajesh Kumar |
| author_sort | Gurika Chopra |
| collection | DOAJ |
| description | Testing to detect ABO incompatibility between a donor and potential transfusion recipient is the foundation on which all other pretransfusion testing is based. Sometimes, weak agglutination reactions may be obtained with reagent antibodies due to weak expression of A and B antigens on red blood cell (RBC) surface which may cause a discrepancy in blood group typing. Here, we report a patient showing discrepancy between RBCs (forward) and serum (reverse) typing. After doing detailed analysis, the blood type as a variant of blood Group A revealed. Subgroups of A are very rare phenotype of blood. Weaker subgroups of A blood group reported so far are mainly A3, Aend, Ax, Am, Ay, and Ael. We are reporting a case of a 35-year-old patient whose RBCs showed a discrepancy between cell and serum grouping during initial testing. Serological investigation included absorption elution tests and saliva tests after performing initial blood grouping. The serological characteristics of the patient's red cells were similar to A3 subtype. The patient was a secretor and A and H substance was present in the saliva. Serum did not show any presence of anti-A1. The weak A phenotype identified had serological characteristics similar to A3. |
| first_indexed | 2024-04-13T10:50:20Z |
| format | Article |
| id | doaj.art-9fab0a01568a455c8536272bfca29128 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-13T10:50:20Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-9fab0a01568a455c8536272bfca291282022-12-22T02:49:40ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652022-01-0116113213410.4103/ajts.ajts_66_21Detection of a weaker subgroup of A in ABO blood group systemGurika ChopraManpreet KatariaArshpreet Kaur BatraGurkiran kaurRajesh KumarTesting to detect ABO incompatibility between a donor and potential transfusion recipient is the foundation on which all other pretransfusion testing is based. Sometimes, weak agglutination reactions may be obtained with reagent antibodies due to weak expression of A and B antigens on red blood cell (RBC) surface which may cause a discrepancy in blood group typing. Here, we report a patient showing discrepancy between RBCs (forward) and serum (reverse) typing. After doing detailed analysis, the blood type as a variant of blood Group A revealed. Subgroups of A are very rare phenotype of blood. Weaker subgroups of A blood group reported so far are mainly A3, Aend, Ax, Am, Ay, and Ael. We are reporting a case of a 35-year-old patient whose RBCs showed a discrepancy between cell and serum grouping during initial testing. Serological investigation included absorption elution tests and saliva tests after performing initial blood grouping. The serological characteristics of the patient's red cells were similar to A3 subtype. The patient was a secretor and A and H substance was present in the saliva. Serum did not show any presence of anti-A1. The weak A phenotype identified had serological characteristics similar to A3.http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=132;epage=134;aulast=a3 subgroupblood groupingdiscrepancyforward typingreverse typing |
| spellingShingle | Gurika Chopra Manpreet Kataria Arshpreet Kaur Batra Gurkiran kaur Rajesh Kumar Detection of a weaker subgroup of A in ABO blood group system Asian Journal of Transfusion Science a3 subgroup blood grouping discrepancy forward typing reverse typing |
| title | Detection of a weaker subgroup of A in ABO blood group system |
| title_full | Detection of a weaker subgroup of A in ABO blood group system |
| title_fullStr | Detection of a weaker subgroup of A in ABO blood group system |
| title_full_unstemmed | Detection of a weaker subgroup of A in ABO blood group system |
| title_short | Detection of a weaker subgroup of A in ABO blood group system |
| title_sort | detection of a weaker subgroup of a in abo blood group system |
| topic | a3 subgroup blood grouping discrepancy forward typing reverse typing |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=132;epage=134;aulast= |
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