Enhanced M1 and Impaired M2 Macrophage Polarization and Reduced Mitochondrial Biogenesis via Inhibition of AMP Kinase in Chronic Kidney Disease

Enhanced M1 and Impaired M2 Macrophage Polarization and Reduced Mitochondrial Biogenesis via Inhibition of AMP Kinase in Chronic Kidney Disease

Background: Macrophage polarization plays a pivotal role in the process of inflammation which is common in chronic kidney disease (CKD). Macrophages polarization under the condition of CKD remains poorly understood. Here we tested the hypothesis that CKD promotes macrophage M1 polarization. Methods:...

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Bibliographic Details
Main Authors: Cong Li, Xiao Yan Ding, Dong Mei Xiang, Jie Xu, Xiang Lan Huang, Fan Fan Hou, Qiu Gen Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Macrophage
Polarization
Mitochondrial biogenesis
Chronic inflammation
Chronic kidney disease
Online Access:http://www.karger.com/Article/FullText/430106

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