Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors
IntroductionThe fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors released in 2021 formally defines pediatric-type diffuse gliomas. However, there is still little understanding of pediatric-type diffuse gliomas, and even less attention has bee...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1144559/full |
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| author | Wenlin Chen Shanmu Jin Shanmu Jin Qianshu Liu Qianshu Liu Hai Wang Yu Xia Yu Xia Xiaopeng Guo Xiaopeng Guo Siying Guo Siying Guo Yaning Wang Yixin Shi Yixin Shi Delin Liu Delin Liu Yilin Li Yilin Li Yuekun Wang Hao Xing Junlin Li Junlin Li Jiaming Wu Jiaming Wu Tingyu Liang Tian Qu Tian Qu Huanzhang Li Huanzhang Li Tianrui Yang Tianrui Yang Kun Zhang Kun Zhang Yu Wang Yu Wang Wenbin Ma Wenbin Ma |
| author_facet | Wenlin Chen Shanmu Jin Shanmu Jin Qianshu Liu Qianshu Liu Hai Wang Yu Xia Yu Xia Xiaopeng Guo Xiaopeng Guo Siying Guo Siying Guo Yaning Wang Yixin Shi Yixin Shi Delin Liu Delin Liu Yilin Li Yilin Li Yuekun Wang Hao Xing Junlin Li Junlin Li Jiaming Wu Jiaming Wu Tingyu Liang Tian Qu Tian Qu Huanzhang Li Huanzhang Li Tianrui Yang Tianrui Yang Kun Zhang Kun Zhang Yu Wang Yu Wang Wenbin Ma Wenbin Ma |
| author_sort | Wenlin Chen |
| collection | DOAJ |
| description | IntroductionThe fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors released in 2021 formally defines pediatric-type diffuse gliomas. However, there is still little understanding of pediatric-type diffuse gliomas, and even less attention has been paid to adult patients. Therefore, this study describes the clinical radiological, survival, and molecular features of adult patients with pediatric-type glioma.MethodsAdult patients who underwent surgery from January 2011 to January 2022, classified as pediatric-type glioma, were included in this study. Clinical, radiological, histopathological, molecular pathological, and survival data were collected for analysis.ResultsAmong 596 adult patients, 20 patients with pediatric-type glioma were screened, including 6 with diffuse astrocytoma, MYB- or MYBL1-altered, 2 with diffuse midline glioma, H3 K27-altered, and 12 with diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype. Pediatric high-grade glioma (pHGG) frequently showed tumor enhancement, peritumoral edema, and intratumoral necrosis. Adult patients with pHGG showed a longer life expectancy than adult patients with glioblastoma. Common molecular alterations included chromosome alterations and CDKN2A/B, PIK3CA, and PTEN, while altered KMT5B and MET were found to affect the overall survival.ConclusionOur study demonstrated adult patients with pediatric-type glioma. Notably, our research aims to expand the current understanding of adult patients with pediatric-type diffuse gliomas. Furthermore, personalized therapies consisting of targeted molecular inhibitors for MET and VEGFA may exhibit beneficial effects in the corresponding population. |
| first_indexed | 2024-04-09T14:17:36Z |
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| id | doaj.art-9fabd6d9986e4e789a28ba1e0ce92069 |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T14:17:36Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-9fabd6d9986e4e789a28ba1e0ce920692023-05-05T06:12:35ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-05-011710.3389/fnins.2023.11445591144559Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumorsWenlin Chen0Shanmu Jin1Shanmu Jin2Qianshu Liu3Qianshu Liu4Hai Wang5Yu Xia6Yu Xia7Xiaopeng Guo8Xiaopeng Guo9Siying Guo10Siying Guo11Yaning Wang12Yixin Shi13Yixin Shi14Delin Liu15Delin Liu16Yilin Li17Yilin Li18Yuekun Wang19Hao Xing20Junlin Li21Junlin Li22Jiaming Wu23Jiaming Wu24Tingyu Liang25Tian Qu26Tian Qu27Huanzhang Li28Huanzhang Li29Tianrui Yang30Tianrui Yang31Kun Zhang32Kun Zhang33Yu Wang34Yu Wang35Wenbin Ma36Wenbin Ma37Department of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China‘4+4’ Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaChina Anti-Cancer Association Specialty Committee of Glioma, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China‘4+4’ Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaChina Anti-Cancer Association Specialty Committee of Glioma, Beijing, ChinaDepartment of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaChina Anti-Cancer Association Specialty Committee of Glioma, Beijing, ChinaIntroductionThe fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors released in 2021 formally defines pediatric-type diffuse gliomas. However, there is still little understanding of pediatric-type diffuse gliomas, and even less attention has been paid to adult patients. Therefore, this study describes the clinical radiological, survival, and molecular features of adult patients with pediatric-type glioma.MethodsAdult patients who underwent surgery from January 2011 to January 2022, classified as pediatric-type glioma, were included in this study. Clinical, radiological, histopathological, molecular pathological, and survival data were collected for analysis.ResultsAmong 596 adult patients, 20 patients with pediatric-type glioma were screened, including 6 with diffuse astrocytoma, MYB- or MYBL1-altered, 2 with diffuse midline glioma, H3 K27-altered, and 12 with diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype. Pediatric high-grade glioma (pHGG) frequently showed tumor enhancement, peritumoral edema, and intratumoral necrosis. Adult patients with pHGG showed a longer life expectancy than adult patients with glioblastoma. Common molecular alterations included chromosome alterations and CDKN2A/B, PIK3CA, and PTEN, while altered KMT5B and MET were found to affect the overall survival.ConclusionOur study demonstrated adult patients with pediatric-type glioma. Notably, our research aims to expand the current understanding of adult patients with pediatric-type diffuse gliomas. Furthermore, personalized therapies consisting of targeted molecular inhibitors for MET and VEGFA may exhibit beneficial effects in the corresponding population.https://www.frontiersin.org/articles/10.3389/fnins.2023.1144559/fullglioma2021 WHO classification of central nervous system tumorspediatric-type diffuse gliomasadult patientsmolecular pathology |
| spellingShingle | Wenlin Chen Shanmu Jin Shanmu Jin Qianshu Liu Qianshu Liu Hai Wang Yu Xia Yu Xia Xiaopeng Guo Xiaopeng Guo Siying Guo Siying Guo Yaning Wang Yixin Shi Yixin Shi Delin Liu Delin Liu Yilin Li Yilin Li Yuekun Wang Hao Xing Junlin Li Junlin Li Jiaming Wu Jiaming Wu Tingyu Liang Tian Qu Tian Qu Huanzhang Li Huanzhang Li Tianrui Yang Tianrui Yang Kun Zhang Kun Zhang Yu Wang Yu Wang Wenbin Ma Wenbin Ma Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors Frontiers in Neuroscience glioma 2021 WHO classification of central nervous system tumors pediatric-type diffuse gliomas adult patients molecular pathology |
| title | Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors |
| title_full | Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors |
| title_fullStr | Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors |
| title_full_unstemmed | Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors |
| title_short | Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors |
| title_sort | spotlights on adult patients with pediatric type diffuse gliomas in accordance with the 2021 who classification of cns tumors |
| topic | glioma 2021 WHO classification of central nervous system tumors pediatric-type diffuse gliomas adult patients molecular pathology |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1144559/full |
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