Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases
The aim of this study was to determine the role of endothelin-1 (ET-1), a molecule involved in multiple vascular and fibrosing abnormalities, as a biomarker of interstitial lung disease (ILD), as well as its use for the differential diagnosis between idiopathic pulmonary fibrosis (IPF) and ILD assoc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1275 |
| _version_ | 1797441433344409600 |
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| author | Verónica Pulito-Cueto Fernanda Genre Raquel López-Mejías Víctor Manuel Mora-Cuesta David Iturbe-Fernández Virginia Portilla María Sebastián Mora-Gil Javier Gonzalo Ocejo-Vinyals Oreste Gualillo Ricardo Blanco Alfonso Corrales Iván Ferraz-Amaro Santos Castañeda José Manuel Cifrián Martínez Belén Atienza-Mateo Sara Remuzgo-Martínez Miguel Ángel González-Gay |
| author_facet | Verónica Pulito-Cueto Fernanda Genre Raquel López-Mejías Víctor Manuel Mora-Cuesta David Iturbe-Fernández Virginia Portilla María Sebastián Mora-Gil Javier Gonzalo Ocejo-Vinyals Oreste Gualillo Ricardo Blanco Alfonso Corrales Iván Ferraz-Amaro Santos Castañeda José Manuel Cifrián Martínez Belén Atienza-Mateo Sara Remuzgo-Martínez Miguel Ángel González-Gay |
| author_sort | Verónica Pulito-Cueto |
| collection | DOAJ |
| description | The aim of this study was to determine the role of endothelin-1 (ET-1), a molecule involved in multiple vascular and fibrosing abnormalities, as a biomarker of interstitial lung disease (ILD), as well as its use for the differential diagnosis between idiopathic pulmonary fibrosis (IPF) and ILD associated with autoimmune diseases (AD-ILD), using a large and well-defined cohort of patients with ILD. A total of 112 patients with IPF, 91 patients with AD-ILD (28 rheumatoid arthritis (RA), 26 systemic sclerosis, 20 idiopathic inflammatory myositis and 17 interstitial pneumonia with autoimmune features) and 44 healthy controls were included. ET-1 serum levels were determined by enzyme-linked immunosorbent assay. A significant increase in ET-1 levels was found in patients with IPF compared to controls. Likewise, AD-ILD patients also showed higher ET-1 levels than controls when the whole cohort was stratified by the type of AD. Similar ET-1 levels were found in IPF and AD-ILD patients, regardless of the underlying AD. Interestingly, increased ET-1 levels were correlated with worse lung function in IPF and RA-ILD patients. Our study supports that serum ET-1 may be useful as a biomarker of ILD, although it could not help in the differential diagnosis between IPF and AD-ILD. Moreover, ET-1 levels may be associated with ILD severity. |
| first_indexed | 2024-03-09T12:23:56Z |
| format | Article |
| id | doaj.art-9faedbd01cdd4b63a781319850e0d7ab |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:23:56Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9faedbd01cdd4b63a781319850e0d7ab2023-11-30T22:37:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242127510.3390/ijms24021275Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune DiseasesVerónica Pulito-Cueto0Fernanda Genre1Raquel López-Mejías2Víctor Manuel Mora-Cuesta3David Iturbe-Fernández4Virginia Portilla5María Sebastián Mora-Gil6Javier Gonzalo Ocejo-Vinyals7Oreste Gualillo8Ricardo Blanco9Alfonso Corrales10Iván Ferraz-Amaro11Santos Castañeda12José Manuel Cifrián Martínez13Belén Atienza-Mateo14Sara Remuzgo-Martínez15Miguel Ángel González-Gay16Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainDepartment of Immunology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, SpainSERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab. (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainDepartment of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, SpainRheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Cátedra UAM-ROCHE EPID Futuro, Universidad Autónoma de Madrid, 28006 Madrid, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainResearch Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, Instituto de Investigación Marqués de Valdecilla, Avenida Cardenal Herrera Oria s/n, Lab. 201/202, 39011 Santander, SpainThe aim of this study was to determine the role of endothelin-1 (ET-1), a molecule involved in multiple vascular and fibrosing abnormalities, as a biomarker of interstitial lung disease (ILD), as well as its use for the differential diagnosis between idiopathic pulmonary fibrosis (IPF) and ILD associated with autoimmune diseases (AD-ILD), using a large and well-defined cohort of patients with ILD. A total of 112 patients with IPF, 91 patients with AD-ILD (28 rheumatoid arthritis (RA), 26 systemic sclerosis, 20 idiopathic inflammatory myositis and 17 interstitial pneumonia with autoimmune features) and 44 healthy controls were included. ET-1 serum levels were determined by enzyme-linked immunosorbent assay. A significant increase in ET-1 levels was found in patients with IPF compared to controls. Likewise, AD-ILD patients also showed higher ET-1 levels than controls when the whole cohort was stratified by the type of AD. Similar ET-1 levels were found in IPF and AD-ILD patients, regardless of the underlying AD. Interestingly, increased ET-1 levels were correlated with worse lung function in IPF and RA-ILD patients. Our study supports that serum ET-1 may be useful as a biomarker of ILD, although it could not help in the differential diagnosis between IPF and AD-ILD. Moreover, ET-1 levels may be associated with ILD severity.https://www.mdpi.com/1422-0067/24/2/1275interstitial lung diseaseidiopathic pulmonary fibrosisinterstitial lung disease associated with autoimmune diseasesbiomarkerendothelin-1 |
| spellingShingle | Verónica Pulito-Cueto Fernanda Genre Raquel López-Mejías Víctor Manuel Mora-Cuesta David Iturbe-Fernández Virginia Portilla María Sebastián Mora-Gil Javier Gonzalo Ocejo-Vinyals Oreste Gualillo Ricardo Blanco Alfonso Corrales Iván Ferraz-Amaro Santos Castañeda José Manuel Cifrián Martínez Belén Atienza-Mateo Sara Remuzgo-Martínez Miguel Ángel González-Gay Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases International Journal of Molecular Sciences interstitial lung disease idiopathic pulmonary fibrosis interstitial lung disease associated with autoimmune diseases biomarker endothelin-1 |
| title | Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases |
| title_full | Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases |
| title_fullStr | Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases |
| title_full_unstemmed | Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases |
| title_short | Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases |
| title_sort | endothelin 1 as a biomarker of idiopathic pulmonary fibrosis and interstitial lung disease associated with autoimmune diseases |
| topic | interstitial lung disease idiopathic pulmonary fibrosis interstitial lung disease associated with autoimmune diseases biomarker endothelin-1 |
| url | https://www.mdpi.com/1422-0067/24/2/1275 |
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