Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1
Objective To analyse the neuropsychological characteristics, sleep structure and HLA ⁃ DQB1 gene distribution of narcolepsy type 1 (NT1) patients. Methods A total of 35 patients with NT1 admitted to Tianjin Medical University General Hospital, from August 2018 to November 2022 were included, all of...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2023-08-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2740 |
| _version_ | 1797736288259932160 |
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| author | HUANG Ya⁃qin XU Lin AI Zhu WANG Lin⁃lin XUE Rong |
| author_facet | HUANG Ya⁃qin XU Lin AI Zhu WANG Lin⁃lin XUE Rong |
| author_sort | HUANG Ya⁃qin |
| collection | DOAJ |
| description | Objective To analyse the neuropsychological characteristics, sleep structure and HLA ⁃ DQB1 gene distribution of narcolepsy type 1 (NT1) patients. Methods A total of 35 patients with NT1 admitted to Tianjin Medical University General Hospital, from August 2018 to November 2022 were included, all of whom underwent neuropsychological tests, noctural polysomnography (nPSG) monitoring, Multiple Sleep Latency Test (MSLT), narcolepsy evaluation and HLA ⁃ DQB1 gene detection. Results Neuropsychological tests showed the scores of Montreal Cognitive Assessment (MoCA; t = 3.159, P = 0.004) and the correct number of immediate recall of the first (t = 3.028, P = 0.004) and the second (t = 2.054, P = 0.044) of Hopkins Verbal Learning Test⁃Revised (HVLT⁃R) were lower of the NT1 group than those of the control group. Trail Making Test (TMT) ⁃B completion time (t = ⁃ 2.126, P = 0.019), Hamilton Anxiety Scale (HAMA) score (Z = ⁃ 5.109, P = 0.000), Hamilton Depression Scale⁃17 (HAMD⁃17) score (Z = ⁃ 3.204, P = 0.001), Epworth Sleepiness Scale (ESS) socre (t = ⁃ 13.609, P = 0.000) and Pittsburgh Sleep Quality Index (PSQI) score (Z = ⁃ 3.004, P = 0.003) were higher of the NT1 group than those of the control group. nPSG showed the total recording time (Z = ⁃ 4.491, P = 0.000), the proportion of non⁃rapid eye movement (NREM) 3 (Z = ⁃ 2.647, P = 0.008), the proportion of rapid eye movement (REM; t = 2.908, P = 0.005) and periodic limb movements of sleep index (PLMSI; Z = ⁃ 3.501, P = 0.000) were higher of the NT1 group than those of the control group. Sleep efficiency (t = ⁃ 2.489, P = 0.016), sleep latency (Z = ⁃ 4.112, P = 0.000), REM sleep latency (Z = ⁃ 4.318, P = 0.000) and the proportion of NREM2 (t = ⁃ 5.224, P = 0.000) were lower of the NT1 group than those of the control group. The clinical features of NT1 patients were excessive daytime sleepiness (97.14%, 34/35), cataplexy (97.14%, 34/35), other sleep disturbances (88.57%, 31/35), sleep hallucination (82.86%, 29/35), and sleep paralysis (68.57%, 24/35). And 34 cases (97.14%) carried the allele HLA ⁃ DQB1*0602. Conclusions Patients with NT1 have cognitive decline, mood change and sleep structure disorder, and the carrying rate of HLA⁃DQB1*0602 is high. |
| first_indexed | 2024-03-12T13:11:29Z |
| format | Article |
| id | doaj.art-9faef7add8ab4d5fb5fa80bdc083385c |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-03-12T13:11:29Z |
| publishDate | 2023-08-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-9faef7add8ab4d5fb5fa80bdc083385c2023-08-28T01:22:17ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312023-08-0123873073710.3969/j.issn.1672⁃6731.2023.08.0122694Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1HUANG Ya⁃qin0XU Lin1AI Zhu2WANG Lin⁃lin3XUE Rong4Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Neurology, Tianjin Medical University Chu Hsien⁃I Memorial Hospital, Tianjin 300134, ChinaDepartment of Neurology, Tianjin First Central Hospital, Tianjin 300192, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaObjective To analyse the neuropsychological characteristics, sleep structure and HLA ⁃ DQB1 gene distribution of narcolepsy type 1 (NT1) patients. Methods A total of 35 patients with NT1 admitted to Tianjin Medical University General Hospital, from August 2018 to November 2022 were included, all of whom underwent neuropsychological tests, noctural polysomnography (nPSG) monitoring, Multiple Sleep Latency Test (MSLT), narcolepsy evaluation and HLA ⁃ DQB1 gene detection. Results Neuropsychological tests showed the scores of Montreal Cognitive Assessment (MoCA; t = 3.159, P = 0.004) and the correct number of immediate recall of the first (t = 3.028, P = 0.004) and the second (t = 2.054, P = 0.044) of Hopkins Verbal Learning Test⁃Revised (HVLT⁃R) were lower of the NT1 group than those of the control group. Trail Making Test (TMT) ⁃B completion time (t = ⁃ 2.126, P = 0.019), Hamilton Anxiety Scale (HAMA) score (Z = ⁃ 5.109, P = 0.000), Hamilton Depression Scale⁃17 (HAMD⁃17) score (Z = ⁃ 3.204, P = 0.001), Epworth Sleepiness Scale (ESS) socre (t = ⁃ 13.609, P = 0.000) and Pittsburgh Sleep Quality Index (PSQI) score (Z = ⁃ 3.004, P = 0.003) were higher of the NT1 group than those of the control group. nPSG showed the total recording time (Z = ⁃ 4.491, P = 0.000), the proportion of non⁃rapid eye movement (NREM) 3 (Z = ⁃ 2.647, P = 0.008), the proportion of rapid eye movement (REM; t = 2.908, P = 0.005) and periodic limb movements of sleep index (PLMSI; Z = ⁃ 3.501, P = 0.000) were higher of the NT1 group than those of the control group. Sleep efficiency (t = ⁃ 2.489, P = 0.016), sleep latency (Z = ⁃ 4.112, P = 0.000), REM sleep latency (Z = ⁃ 4.318, P = 0.000) and the proportion of NREM2 (t = ⁃ 5.224, P = 0.000) were lower of the NT1 group than those of the control group. The clinical features of NT1 patients were excessive daytime sleepiness (97.14%, 34/35), cataplexy (97.14%, 34/35), other sleep disturbances (88.57%, 31/35), sleep hallucination (82.86%, 29/35), and sleep paralysis (68.57%, 24/35). And 34 cases (97.14%) carried the allele HLA ⁃ DQB1*0602. Conclusions Patients with NT1 have cognitive decline, mood change and sleep structure disorder, and the carrying rate of HLA⁃DQB1*0602 is high.http://www.cjcnn.org/index.php/cjcnn/article/view/2740narcolepsyneuropsychological testspolysomnographyhla⁃dq antigens |
| spellingShingle | HUANG Ya⁃qin XU Lin AI Zhu WANG Lin⁃lin XUE Rong Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1 Chinese Journal of Contemporary Neurology and Neurosurgery narcolepsy neuropsychological tests polysomnography hla⁃dq antigens |
| title | Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1 |
| title_full | Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1 |
| title_fullStr | Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1 |
| title_full_unstemmed | Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1 |
| title_short | Characteristics of neuropsychological, sleep structure and distribution of HLA ⁃ DQB1 genotype of narcolepsy type 1 |
| title_sort | characteristics of neuropsychological sleep structure and distribution of hla ⁃ dqb1 genotype of narcolepsy type 1 |
| topic | narcolepsy neuropsychological tests polysomnography hla⁃dq antigens |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2740 |
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