Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China
Yan Qiao,1,* Zhaoyu Tao,2,* Feiran Hao,3 Yongqiang Huang,2 Hong Sun,2 Pu Guo2 1Department of Infectious Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233004, People’s Republic of China; 2Department of Clinical Laboratory Science, The First Affiliate...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-07-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/epidemiological-characteristics-antifungal-susceptibility-risk-factors-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797773693455171584 |
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| author | Qiao Y Tao Z Hao F Huang Y Sun H Guo P |
| author_facet | Qiao Y Tao Z Hao F Huang Y Sun H Guo P |
| author_sort | Qiao Y |
| collection | DOAJ |
| description | Yan Qiao,1,* Zhaoyu Tao,2,* Feiran Hao,3 Yongqiang Huang,2 Hong Sun,2 Pu Guo2 1Department of Infectious Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233004, People’s Republic of China; 2Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, People’s Republic of China; 3Department of Clinical Medicine, School of Basic Medicine, Qiqihar Medical college, Hei Longjiang Qiqihar, 161006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pu Guo; Hong Sun, Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, 287 Zhihuai Road, Bengbu, 233004, People’s Republic of China, Email 3504624902@qq.com; sunhong0222@126.comBackground: Candida is one of the most important pathogens of hospital-acquired bloodstream infections. Its morbidity and mortality are still high, which is a serious global public problem.Purpose: To investigate the strain distribution, drug susceptibility, clinical characteristics of patients, and risk factors affecting the prognosis of Candida bloodstream infection (BSI).Materials and Methods: We retrospectively collected the clinical data, infection-related indicators, prognosis, strain prevalence and drug susceptibility of 163 patients with Candida BSI in a teaching hospital from January 2012 to December 2022. Univariate and multivariate logistic regression were used to analyze the risk factors affecting the prognosis.Results: In 163 cases of Candida BSI, Candida albicans accounted for 48.47%, and Candida non-albicans accounted for 51.53%. A total of 163 patients with Candida BSI were mainly distributed in intensive care unit (ICU) and emergency department, accounting for 40.49% and 14.72%, respectively. The resistance rate of Candida albicans to fluconazole, itraconazole and voriconazole was less than 10%, and the sensitivity rate of Candida tropicalis to fluconazole, itraconazole and voriconazole was less than 80%. The mortality rate of 163 patients with Candida BSI was 33.13%, with Candida non-albicans higher than that of Candida albicans (p = 0.04). Multivariate analysis showed that hemodialysis (OR = 0.199, 95% CI: 0.059– 0.673, P = 0.009), arteriovenous catheters (OR = 0.344, 95% CI: 0.130– 0.913, P = 0.032), elevated neutrophil count (OR = 0.409, 95% CI: 0.194– 0.862, P = 0.019) and APACHE II score (OR = 0.848, 95% CI: 0.789~0.911, P < 0.001) were independent risk factors for death in patients with candidemia.Conclusion: The blood flow infection rate of Candida non-albicans is increasing, and the mortality rate and resistance to antifungal drugs are higher than that of Candida albicans. Hemodialysis, arteriovenous catheters, elevated neutrophil count and APACHE II score were associated with death in patients with Candida BSI.Keywords: Candida, bloodstream infection, clinical features, prognosis |
| first_indexed | 2024-03-12T22:10:10Z |
| format | Article |
| id | doaj.art-9faf51346aec4e1086857b12f13918ad |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-12T22:10:10Z |
| publishDate | 2023-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-9faf51346aec4e1086857b12f13918ad2023-07-23T15:49:04ZengDove Medical PressInfection and Drug Resistance1178-69732023-07-01Volume 164769477885339Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in ChinaQiao YTao ZHao FHuang YSun HGuo PYan Qiao,1,* Zhaoyu Tao,2,* Feiran Hao,3 Yongqiang Huang,2 Hong Sun,2 Pu Guo2 1Department of Infectious Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233004, People’s Republic of China; 2Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, People’s Republic of China; 3Department of Clinical Medicine, School of Basic Medicine, Qiqihar Medical college, Hei Longjiang Qiqihar, 161006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pu Guo; Hong Sun, Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, 287 Zhihuai Road, Bengbu, 233004, People’s Republic of China, Email 3504624902@qq.com; sunhong0222@126.comBackground: Candida is one of the most important pathogens of hospital-acquired bloodstream infections. Its morbidity and mortality are still high, which is a serious global public problem.Purpose: To investigate the strain distribution, drug susceptibility, clinical characteristics of patients, and risk factors affecting the prognosis of Candida bloodstream infection (BSI).Materials and Methods: We retrospectively collected the clinical data, infection-related indicators, prognosis, strain prevalence and drug susceptibility of 163 patients with Candida BSI in a teaching hospital from January 2012 to December 2022. Univariate and multivariate logistic regression were used to analyze the risk factors affecting the prognosis.Results: In 163 cases of Candida BSI, Candida albicans accounted for 48.47%, and Candida non-albicans accounted for 51.53%. A total of 163 patients with Candida BSI were mainly distributed in intensive care unit (ICU) and emergency department, accounting for 40.49% and 14.72%, respectively. The resistance rate of Candida albicans to fluconazole, itraconazole and voriconazole was less than 10%, and the sensitivity rate of Candida tropicalis to fluconazole, itraconazole and voriconazole was less than 80%. The mortality rate of 163 patients with Candida BSI was 33.13%, with Candida non-albicans higher than that of Candida albicans (p = 0.04). Multivariate analysis showed that hemodialysis (OR = 0.199, 95% CI: 0.059– 0.673, P = 0.009), arteriovenous catheters (OR = 0.344, 95% CI: 0.130– 0.913, P = 0.032), elevated neutrophil count (OR = 0.409, 95% CI: 0.194– 0.862, P = 0.019) and APACHE II score (OR = 0.848, 95% CI: 0.789~0.911, P < 0.001) were independent risk factors for death in patients with candidemia.Conclusion: The blood flow infection rate of Candida non-albicans is increasing, and the mortality rate and resistance to antifungal drugs are higher than that of Candida albicans. Hemodialysis, arteriovenous catheters, elevated neutrophil count and APACHE II score were associated with death in patients with Candida BSI.Keywords: Candida, bloodstream infection, clinical features, prognosishttps://www.dovepress.com/epidemiological-characteristics-antifungal-susceptibility-risk-factors-peer-reviewed-fulltext-article-IDRcandidabloodstream infectionclinical featuresprognosis |
| spellingShingle | Qiao Y Tao Z Hao F Huang Y Sun H Guo P Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China Infection and Drug Resistance candida bloodstream infection clinical features prognosis |
| title | Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China |
| title_full | Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China |
| title_fullStr | Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China |
| title_full_unstemmed | Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China |
| title_short | Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Candida Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China |
| title_sort | epidemiological characteristics antifungal susceptibility risk factors and outcomes of candida bloodstream infection a ten year surveillance in a teaching hospital in china |
| topic | candida bloodstream infection clinical features prognosis |
| url | https://www.dovepress.com/epidemiological-characteristics-antifungal-susceptibility-risk-factors-peer-reviewed-fulltext-article-IDR |
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