AI-guided discovery of the invariant host response to viral pandemics

AI-guided discovery of the invariant host response to viral pandemics

Background: Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the “cytokine storm” that has been implicated in fatal COVID-19 using an AI-based approach. Method: Over 45,000 tran...

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Bibliographic Details
Main Authors: Debashis Sahoo, Gajanan D. Katkar, Soni Khandelwal, Mahdi Behroozikhah, Amanraj Claire, Vanessa Castillo, Courtney Tindle, MacKenzie Fuller, Sahar Taheri, Thomas F. Rogers, Nathan Beutler, Sydney I. Ramirez, Stephen A. Rawlings, Victor Pretorius, Davey M. Smith, Dennis R. Burton, Laura E. Crotty Alexander, Jason Duran, Shane Crotty, Jennifer M. Dan, Soumita Das, Pradipta Ghosh
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:EBioMedicine
Subjects:
Artificial intelligence/machine learning
Boolean equivalent clusters
Angiotensin converting enzyme (ACE)-2
Coronavirus COVID-19
Immune response
Lung alveoli
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001833

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