In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4+ T cells

In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4+ T cells

Abstract Blockade of the immune checkpoint axis consisting of programmed death-1 (PD-1) and its ligand PD-L1 alleviates the functional inhibition of tumor-infiltrating lymphoid cells yet weakly induces their expansion. Exogenous cytokines could further expand lymphoid cells and thus synergize with α...

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Bibliographic Details
Main Authors: Robin Maximilian Awad, Yannick De Vlaeminck, Fien Meeus, Thomas Ertveldt, Katty Zeven, Hannelore Ceuppens, Cleo Goyvaerts, Magali Verdonck, Gustavo Salguero, Geert Raes, Nick Devoogdt, Karine Breckpot
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45948-w

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