Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury

Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury

Abstract The toll-like receptor 5 (TLR5) agonist, CBLB502/Entolimod, is a peptide derived from bacterial flagellin and has been shown to protect against radiation-induced tissue damage in animal models. Here we investigated the protective mechanism of CBLB502 in the liver using models of ischemia-re...

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Bibliographic Details
Main Authors: Nicolas Melin, Daniel Sánchez-Taltavull, René Fahrner, Adrian Keogh, Michel Dosch, Isabel Büchi, Yitzhak Zimmer, Michaela Medová, Guido Beldi, Daniel M. Aebersold, Daniel Candinas, Deborah Stroka
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03654-3

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