High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue. Although the preferred recognition motifs of many kinases and SH2 domains are known, we lack a quantitative description o...

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Bibliographic Details
Main Authors: Allyson Li, Rashmi Voleti, Minhee Lee, Dejan Gagoski, Neel H Shah
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
sequence specificity
phosphotyrosine
cell signaling
variant effects
deep sequencing
amber suppression
Online Access:https://elifesciences.org/articles/82345

Internet

https://elifesciences.org/articles/82345

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