Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.
Background:Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared as a pandemic in 2019-2020. Most cases are usually self- limited; however, it may unpredictably progress to severe form with high mortality rate. O...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2022-05-01
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| Series: | Microbes and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mid.journals.ekb.eg/article_222752_07c914b470df067825e47c5985f15685.pdf |
| _version_ | 1811204993986854912 |
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| author | Maii Shams Eldeen Haidy Khalil Mohamed Abdelghafar Hoda Ibrahim Marwa Abdelwahab |
| author_facet | Maii Shams Eldeen Haidy Khalil Mohamed Abdelghafar Hoda Ibrahim Marwa Abdelwahab |
| author_sort | Maii Shams Eldeen |
| collection | DOAJ |
| description | Background:Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared as a pandemic in 2019-2020. Most cases are usually self- limited; however, it may unpredictably progress to severe form with high mortality rate. Objectives: To highlight the role of measuring serum procalcitonin (PCT) and receiving early prophylactic antibiotic therapy in terms of their relation to the mortality rate in hospitalized critical COVID-19 patients. Methods: this study analyzed sixty COVID-19 critical patients admitted to Tanta University Isolation Hospital from June to November, 2020. Respiratory tract and blood samples were collected Results: Our results showed that the mean serum PCT levels were significantly higher in deceased patients (15%) than in those who could survive corona-virus infection. Patients who received early prophylactic antibiotic therapy showed significant better survival rate than those who didn’t. Conclusion: This study demonstrated that measuring PCT shows statically significant results with COVID-19 patients’ outcome more than other commonly used laboratory markers such as CRP. Moreover, early administration of prophylactic antibiotic therapy in COVID-19 patients, especially critical ones, is crucial even in those with negative PCT values. |
| first_indexed | 2024-04-12T03:23:07Z |
| format | Article |
| id | doaj.art-9fb7de630370469da8485457f5be1d9d |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-12T03:23:07Z |
| publishDate | 2022-05-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-9fb7de630370469da8485457f5be1d9d2022-12-22T03:49:50ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402022-05-013226226910.21608/mid.2022.115485.1233222752Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.Maii Shams Eldeen0Haidy Khalil1Mohamed Abdelghafar2Hoda Ibrahim3Marwa Abdelwahab4Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Helwan University, Egypt.Assistant professor of Anesthesia, Surgical Intensive Care and Pain, Faculty of Medicine, Tanta University. Egypt.Lecturer of Medical Biochemistry, Faculty of Medicine, Tanta University. Egypt.Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.Background:Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared as a pandemic in 2019-2020. Most cases are usually self- limited; however, it may unpredictably progress to severe form with high mortality rate. Objectives: To highlight the role of measuring serum procalcitonin (PCT) and receiving early prophylactic antibiotic therapy in terms of their relation to the mortality rate in hospitalized critical COVID-19 patients. Methods: this study analyzed sixty COVID-19 critical patients admitted to Tanta University Isolation Hospital from June to November, 2020. Respiratory tract and blood samples were collected Results: Our results showed that the mean serum PCT levels were significantly higher in deceased patients (15%) than in those who could survive corona-virus infection. Patients who received early prophylactic antibiotic therapy showed significant better survival rate than those who didn’t. Conclusion: This study demonstrated that measuring PCT shows statically significant results with COVID-19 patients’ outcome more than other commonly used laboratory markers such as CRP. Moreover, early administration of prophylactic antibiotic therapy in COVID-19 patients, especially critical ones, is crucial even in those with negative PCT values.https://mid.journals.ekb.eg/article_222752_07c914b470df067825e47c5985f15685.pdfcovid-19procalcitoninsurvival |
| spellingShingle | Maii Shams Eldeen Haidy Khalil Mohamed Abdelghafar Hoda Ibrahim Marwa Abdelwahab Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients. Microbes and Infectious Diseases covid-19 procalcitonin survival |
| title | Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients. |
| title_full | Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients. |
| title_fullStr | Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients. |
| title_full_unstemmed | Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients. |
| title_short | Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients. |
| title_sort | role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical covid 19 patients |
| topic | covid-19 procalcitonin survival |
| url | https://mid.journals.ekb.eg/article_222752_07c914b470df067825e47c5985f15685.pdf |
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