Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma
Sympathetic ophthalmia (SO) is a bilateral granulomatous panuveitis. We report a rare case of SO presenting after scleral necrosis as a late complication of Gamma Knife radiotherapy for choroidal melanoma. A 55-year-old woman presented with primary choroidal melanoma in the right eye and has been tr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Taiwan Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2023;volume=13;issue=4;spage=548;epage=551;aulast=Chen |
| _version_ | 1797226170703413248 |
|---|---|
| author | Yen-Cheng Chen Yu-Jang Chao Chieh-Chih Tsai Shih-Jen Chen De-Kuang Hwang |
| author_facet | Yen-Cheng Chen Yu-Jang Chao Chieh-Chih Tsai Shih-Jen Chen De-Kuang Hwang |
| author_sort | Yen-Cheng Chen |
| collection | DOAJ |
| description | Sympathetic ophthalmia (SO) is a bilateral granulomatous panuveitis. We report a rare case of SO presenting after scleral necrosis as a late complication of Gamma Knife radiotherapy for choroidal melanoma. A 55-year-old woman presented with primary choroidal melanoma in the right eye and has been treated with Gamma Knife radiotherapy with stable tumor size. Five years after radiotherapy, a pigmented protrusive uveal mass was visibly noted over the superior sclera of the same eye, corresponding to periocular soft tissue enhancement on computed tomography. Biopsies of the pigmented mass showed the absence of malignancy. One month later, acute blurred vision with signs of sympathetic ophthalmia developed in the left eye. The patient received high-dose systemic corticosteroids and immunomodulatory therapy. The intraocular inflammation in the left eye subsided with improving vision, and the uveal mass in the right eye flattened after the anti-inflammatory therapy. Scleral necrosis is a rare complication following radiotherapy for choroidal melanoma and may incite sympathetic ophthalmia, for which prompt and aggressive treatment is important to save vision, especially for the fellow eye. |
| first_indexed | 2024-04-24T14:20:39Z |
| format | Article |
| id | doaj.art-9fb8c4df0fdf4517be19e59a4fba6ba7 |
| institution | Directory Open Access Journal |
| issn | 2211-5056 2211-5072 |
| language | English |
| last_indexed | 2024-04-24T14:20:39Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwan Journal of Ophthalmology |
| spelling | doaj.art-9fb8c4df0fdf4517be19e59a4fba6ba72024-04-03T06:45:05ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722023-01-0113454855110.4103/2211-5056.360046Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanomaYen-Cheng ChenYu-Jang ChaoChieh-Chih TsaiShih-Jen ChenDe-Kuang HwangSympathetic ophthalmia (SO) is a bilateral granulomatous panuveitis. We report a rare case of SO presenting after scleral necrosis as a late complication of Gamma Knife radiotherapy for choroidal melanoma. A 55-year-old woman presented with primary choroidal melanoma in the right eye and has been treated with Gamma Knife radiotherapy with stable tumor size. Five years after radiotherapy, a pigmented protrusive uveal mass was visibly noted over the superior sclera of the same eye, corresponding to periocular soft tissue enhancement on computed tomography. Biopsies of the pigmented mass showed the absence of malignancy. One month later, acute blurred vision with signs of sympathetic ophthalmia developed in the left eye. The patient received high-dose systemic corticosteroids and immunomodulatory therapy. The intraocular inflammation in the left eye subsided with improving vision, and the uveal mass in the right eye flattened after the anti-inflammatory therapy. Scleral necrosis is a rare complication following radiotherapy for choroidal melanoma and may incite sympathetic ophthalmia, for which prompt and aggressive treatment is important to save vision, especially for the fellow eye.http://www.e-tjo.org/article.asp?issn=2211-5056;year=2023;volume=13;issue=4;spage=548;epage=551;aulast=Chenchoroidal melanomagamma knife radiotherapyorbitalradiation-induced scleral necrosissympathetic ophthalmiatumor |
| spellingShingle | Yen-Cheng Chen Yu-Jang Chao Chieh-Chih Tsai Shih-Jen Chen De-Kuang Hwang Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma Taiwan Journal of Ophthalmology choroidal melanoma gamma knife radiotherapy orbital radiation-induced scleral necrosis sympathetic ophthalmia tumor |
| title | Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma |
| title_full | Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma |
| title_fullStr | Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma |
| title_full_unstemmed | Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma |
| title_short | Sympathetic ophthalmia following radiation-induced scleral necrosis in choroidal melanoma |
| title_sort | sympathetic ophthalmia following radiation induced scleral necrosis in choroidal melanoma |
| topic | choroidal melanoma gamma knife radiotherapy orbital radiation-induced scleral necrosis sympathetic ophthalmia tumor |
| url | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2023;volume=13;issue=4;spage=548;epage=551;aulast=Chen |
| work_keys_str_mv | AT yenchengchen sympatheticophthalmiafollowingradiationinducedscleralnecrosisinchoroidalmelanoma AT yujangchao sympatheticophthalmiafollowingradiationinducedscleralnecrosisinchoroidalmelanoma AT chiehchihtsai sympatheticophthalmiafollowingradiationinducedscleralnecrosisinchoroidalmelanoma AT shihjenchen sympatheticophthalmiafollowingradiationinducedscleralnecrosisinchoroidalmelanoma AT dekuanghwang sympatheticophthalmiafollowingradiationinducedscleralnecrosisinchoroidalmelanoma |