Global patterns of diversity and selection in human tyrosinase gene.
Global variation in skin pigmentation is one of the most striking examples of environmental adaptation in humans. More than two hundred loci have been identified as candidate genes in model organisms and a few tens of these have been found to be significantly associated with human skin pigmentation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3770694?pdf=render |
| _version_ | 1818566536685682688 |
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| author | Georgi Hudjashov Richard Villems Toomas Kivisild |
| author_facet | Georgi Hudjashov Richard Villems Toomas Kivisild |
| author_sort | Georgi Hudjashov |
| collection | DOAJ |
| description | Global variation in skin pigmentation is one of the most striking examples of environmental adaptation in humans. More than two hundred loci have been identified as candidate genes in model organisms and a few tens of these have been found to be significantly associated with human skin pigmentation in genome-wide association studies. However, the evolutionary history of different pigmentation genes is rather complex: some loci have been subjected to strong positive selection, while others evolved under the relaxation of functional constraints in low UV environment. Here we report the results of a global study of the human tyrosinase gene, which is one of the key enzymes in melanin production, to assess the role of its variation in the evolution of skin pigmentation differences among human populations. We observe a higher rate of non-synonymous polymorphisms in the European sample consistent with the relaxation of selective constraints. A similar pattern was previously observed in the MC1R gene and concurs with UV radiation-driven model of skin color evolution by which mutations leading to lower melanin levels and decreased photoprotection are subject to purifying selection at low latitudes while being tolerated or even favored at higher latitudes because they facilitate UV-dependent vitamin D production. Our coalescent date estimates suggest that the non-synonymous variants, which are frequent in Europe and North Africa, are recent and have emerged after the separation of East and West Eurasian populations. |
| first_indexed | 2024-12-14T01:54:57Z |
| format | Article |
| id | doaj.art-9fb9f7ae73104f9593586e7693aee206 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T01:54:57Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9fb9f7ae73104f9593586e7693aee2062022-12-21T23:21:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7430710.1371/journal.pone.0074307Global patterns of diversity and selection in human tyrosinase gene.Georgi HudjashovRichard VillemsToomas KivisildGlobal variation in skin pigmentation is one of the most striking examples of environmental adaptation in humans. More than two hundred loci have been identified as candidate genes in model organisms and a few tens of these have been found to be significantly associated with human skin pigmentation in genome-wide association studies. However, the evolutionary history of different pigmentation genes is rather complex: some loci have been subjected to strong positive selection, while others evolved under the relaxation of functional constraints in low UV environment. Here we report the results of a global study of the human tyrosinase gene, which is one of the key enzymes in melanin production, to assess the role of its variation in the evolution of skin pigmentation differences among human populations. We observe a higher rate of non-synonymous polymorphisms in the European sample consistent with the relaxation of selective constraints. A similar pattern was previously observed in the MC1R gene and concurs with UV radiation-driven model of skin color evolution by which mutations leading to lower melanin levels and decreased photoprotection are subject to purifying selection at low latitudes while being tolerated or even favored at higher latitudes because they facilitate UV-dependent vitamin D production. Our coalescent date estimates suggest that the non-synonymous variants, which are frequent in Europe and North Africa, are recent and have emerged after the separation of East and West Eurasian populations.http://europepmc.org/articles/PMC3770694?pdf=render |
| spellingShingle | Georgi Hudjashov Richard Villems Toomas Kivisild Global patterns of diversity and selection in human tyrosinase gene. PLoS ONE |
| title | Global patterns of diversity and selection in human tyrosinase gene. |
| title_full | Global patterns of diversity and selection in human tyrosinase gene. |
| title_fullStr | Global patterns of diversity and selection in human tyrosinase gene. |
| title_full_unstemmed | Global patterns of diversity and selection in human tyrosinase gene. |
| title_short | Global patterns of diversity and selection in human tyrosinase gene. |
| title_sort | global patterns of diversity and selection in human tyrosinase gene |
| url | http://europepmc.org/articles/PMC3770694?pdf=render |
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