Emerging role of bacterial outer membrane vesicle in gastrointestinal tract
Abstract Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles that encapsulate nucleic acids, proteins, lipids, and other molecules. Extracellular vesicles (EVs) ar...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
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| Series: | Gut Pathogens |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13099-023-00543-2 |
| _version_ | 1797836428252545024 |
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| author | Cheng-mei Tian Mei-feng Yang Hao-ming Xu Min-zheng Zhu Yuan Zhang Jun Yao Li-sheng Wang Yu-jie Liang De-feng Li |
| author_facet | Cheng-mei Tian Mei-feng Yang Hao-ming Xu Min-zheng Zhu Yuan Zhang Jun Yao Li-sheng Wang Yu-jie Liang De-feng Li |
| author_sort | Cheng-mei Tian |
| collection | DOAJ |
| description | Abstract Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles that encapsulate nucleic acids, proteins, lipids, and other molecules. Extracellular vesicles (EVs) are secreted by microorganisms and can transport a variety of important factors, such as virulence factors, antibiotics, HGT, and defensive factors produced by host eukaryotic cells. In addition, these EVs are vital in facilitating communication between microbiota and the host. Therefore, bacterial EVs play a crucial role in maintaining the GI tract’s health and proper functioning. In this review, we outlined the structure and composition of bacterial EVs. Additionally, we highlighted the critical role that bacterial EVs play in immune regulation and in maintaining the balance of the gut microbiota. To further elucidate progress in the field of intestinal research and to provide a reference for future EV studies, we also discussed the clinical and pharmacological potential of bacterial EVs, as well as the necessary efforts required to understand the mechanisms of interaction between bacterial EVs and gut pathogenesis. |
| first_indexed | 2024-04-09T15:09:20Z |
| format | Article |
| id | doaj.art-9fba872939bf49a1be95f6a816f3231f |
| institution | Directory Open Access Journal |
| issn | 1757-4749 |
| language | English |
| last_indexed | 2024-04-09T15:09:20Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Gut Pathogens |
| spelling | doaj.art-9fba872939bf49a1be95f6a816f3231f2023-04-30T11:17:42ZengBMCGut Pathogens1757-47492023-04-0115112110.1186/s13099-023-00543-2Emerging role of bacterial outer membrane vesicle in gastrointestinal tractCheng-mei Tian0Mei-feng Yang1Hao-ming Xu2Min-zheng Zhu3Yuan Zhang4Jun Yao5Li-sheng Wang6Yu-jie Liang7De-feng Li8Department of Emergency, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology)Department of Hematology, Yantian District People’s HospitalDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyDepartment of Medical Administration, Huizhou Institute of Occupational Diseases Control and PreventionDepartment of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology)Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology)Department of Child and Adolescent Psychiatry, Shenzhen Kangning HospitalDepartment of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology)Abstract Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles that encapsulate nucleic acids, proteins, lipids, and other molecules. Extracellular vesicles (EVs) are secreted by microorganisms and can transport a variety of important factors, such as virulence factors, antibiotics, HGT, and defensive factors produced by host eukaryotic cells. In addition, these EVs are vital in facilitating communication between microbiota and the host. Therefore, bacterial EVs play a crucial role in maintaining the GI tract’s health and proper functioning. In this review, we outlined the structure and composition of bacterial EVs. Additionally, we highlighted the critical role that bacterial EVs play in immune regulation and in maintaining the balance of the gut microbiota. To further elucidate progress in the field of intestinal research and to provide a reference for future EV studies, we also discussed the clinical and pharmacological potential of bacterial EVs, as well as the necessary efforts required to understand the mechanisms of interaction between bacterial EVs and gut pathogenesis.https://doi.org/10.1186/s13099-023-00543-2BacterialMicrobiotaOuter membrane vesicleExtracellular vesiclesGastrointestinal tract |
| spellingShingle | Cheng-mei Tian Mei-feng Yang Hao-ming Xu Min-zheng Zhu Yuan Zhang Jun Yao Li-sheng Wang Yu-jie Liang De-feng Li Emerging role of bacterial outer membrane vesicle in gastrointestinal tract Gut Pathogens Bacterial Microbiota Outer membrane vesicle Extracellular vesicles Gastrointestinal tract |
| title | Emerging role of bacterial outer membrane vesicle in gastrointestinal tract |
| title_full | Emerging role of bacterial outer membrane vesicle in gastrointestinal tract |
| title_fullStr | Emerging role of bacterial outer membrane vesicle in gastrointestinal tract |
| title_full_unstemmed | Emerging role of bacterial outer membrane vesicle in gastrointestinal tract |
| title_short | Emerging role of bacterial outer membrane vesicle in gastrointestinal tract |
| title_sort | emerging role of bacterial outer membrane vesicle in gastrointestinal tract |
| topic | Bacterial Microbiota Outer membrane vesicle Extracellular vesicles Gastrointestinal tract |
| url | https://doi.org/10.1186/s13099-023-00543-2 |
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