Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity
Group 2 innate lymphoid cells (ILC2s) are tissue resident in the lung and activated by inhaled allergens via epithelial-derived alarmins including IL-33. Activated ILC2s proliferate, produce IL-5 and IL-13, and induce eosinophilic inflammation. Here, we report that intranasal IL-33 or the protease a...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.679509/full |
| _version_ | 1819027471397289984 |
|---|---|
| author | Laura Mathä Laura Mathä Mónica Romera-Hernández Mónica Romera-Hernández Catherine A. Steer Yi Han Yin Mona Orangi Mona Orangi Hanjoo Shim ChihKai Chang Fabio M. Rossi Fabio M. Rossi Fumio Takei Fumio Takei |
| author_facet | Laura Mathä Laura Mathä Mónica Romera-Hernández Mónica Romera-Hernández Catherine A. Steer Yi Han Yin Mona Orangi Mona Orangi Hanjoo Shim ChihKai Chang Fabio M. Rossi Fabio M. Rossi Fumio Takei Fumio Takei |
| author_sort | Laura Mathä |
| collection | DOAJ |
| description | Group 2 innate lymphoid cells (ILC2s) are tissue resident in the lung and activated by inhaled allergens via epithelial-derived alarmins including IL-33. Activated ILC2s proliferate, produce IL-5 and IL-13, and induce eosinophilic inflammation. Here, we report that intranasal IL-33 or the protease allergen papain administration resulted in increased numbers of ILC2s not only in the lung but also in peripheral blood and liver. Analyses of IL-33 treated parabiosis mice showed that the increase in lung ILC2s was due to proliferation of lung resident ILC2s, whereas the increase in liver ILC2s was due to the migration of activated lung ILC2s. Lung-derived ILC2s induced eosinophilic hepatitis and expression of fibrosis-related genes. Intranasal IL-33 pre-treatment also attenuated concanavalin A-induced acute hepatitis and cirrhosis. These results suggest that activated lung resident ILC2s emigrate from the lung, circulate, settle in the liver and promote type 2 inflammation and attenuate type 1 inflammation. |
| first_indexed | 2024-12-21T05:43:00Z |
| format | Article |
| id | doaj.art-9fbac660b3204eff83affd0eccc47ea7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T05:43:00Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9fbac660b3204eff83affd0eccc47ea72022-12-21T19:14:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.679509679509Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver ImmunityLaura Mathä0Laura Mathä1Mónica Romera-Hernández2Mónica Romera-Hernández3Catherine A. Steer4Yi Han Yin5Mona Orangi6Mona Orangi7Hanjoo Shim8ChihKai Chang9Fabio M. Rossi10Fabio M. Rossi11Fumio Takei12Fumio Takei13Terry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaInterdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, CanadaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaInterdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, CanadaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaBiomedical Research Centre, University of British Columbia, Vancouver, BC, CanadaBiomedical Research Centre, University of British Columbia, Vancouver, BC, CanadaDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, CanadaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaGroup 2 innate lymphoid cells (ILC2s) are tissue resident in the lung and activated by inhaled allergens via epithelial-derived alarmins including IL-33. Activated ILC2s proliferate, produce IL-5 and IL-13, and induce eosinophilic inflammation. Here, we report that intranasal IL-33 or the protease allergen papain administration resulted in increased numbers of ILC2s not only in the lung but also in peripheral blood and liver. Analyses of IL-33 treated parabiosis mice showed that the increase in lung ILC2s was due to proliferation of lung resident ILC2s, whereas the increase in liver ILC2s was due to the migration of activated lung ILC2s. Lung-derived ILC2s induced eosinophilic hepatitis and expression of fibrosis-related genes. Intranasal IL-33 pre-treatment also attenuated concanavalin A-induced acute hepatitis and cirrhosis. These results suggest that activated lung resident ILC2s emigrate from the lung, circulate, settle in the liver and promote type 2 inflammation and attenuate type 1 inflammation.https://www.frontiersin.org/articles/10.3389/fimmu.2021.679509/fullgroup 2 innate lymphoid cellsallergic lung inflammationtissue residentmigrationliver inflammationparabiosis |
| spellingShingle | Laura Mathä Laura Mathä Mónica Romera-Hernández Mónica Romera-Hernández Catherine A. Steer Yi Han Yin Mona Orangi Mona Orangi Hanjoo Shim ChihKai Chang Fabio M. Rossi Fabio M. Rossi Fumio Takei Fumio Takei Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity Frontiers in Immunology group 2 innate lymphoid cells allergic lung inflammation tissue resident migration liver inflammation parabiosis |
| title | Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity |
| title_full | Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity |
| title_fullStr | Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity |
| title_full_unstemmed | Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity |
| title_short | Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity |
| title_sort | migration of lung resident group 2 innate lymphoid cells link allergic lung inflammation and liver immunity |
| topic | group 2 innate lymphoid cells allergic lung inflammation tissue resident migration liver inflammation parabiosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.679509/full |
| work_keys_str_mv | AT lauramatha migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT lauramatha migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT monicaromerahernandez migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT monicaromerahernandez migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT catherineasteer migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT yihanyin migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT monaorangi migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT monaorangi migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT hanjooshim migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT chihkaichang migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT fabiomrossi migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT fabiomrossi migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT fumiotakei migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity AT fumiotakei migrationoflungresidentgroup2innatelymphoidcellslinkallergiclunginflammationandliverimmunity |