Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers
Cholic acid and galactose or lactose dual conjugated chitosan derivatives were designed and synthesized as potential anti liver cancer drug carriers, their structures were characterized through proton NMR spectra, elemental analysis, size distribution, zeta potential, and scanning electron microscop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/17/2939 |
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| author | Yili Ding Wutong Cui Chamakura V. N. S. Vara Prasad Bingyun Wang |
| author_facet | Yili Ding Wutong Cui Chamakura V. N. S. Vara Prasad Bingyun Wang |
| author_sort | Yili Ding |
| collection | DOAJ |
| description | Cholic acid and galactose or lactose dual conjugated chitosan derivatives were designed and synthesized as potential anti liver cancer drug carriers, their structures were characterized through proton NMR spectra, elemental analysis, size distribution, zeta potential, and scanning electron microscope image studies. The ability of the dual conjugates to enhance the aqueous solubility of the cancer drug sorafenib was evaluated. The entrapment efficiency (EE%) and drug content (DC%) of sorafenib in the inclusion complexes were measured. The chitosan dual conjugate with cholic acid and galactose was found to be best in enhancing the aqueous solubility of sorafenib. The solubility of sorafenib in water has increased from 1.7 µg/mL to 1900 µg/mL which is equal to 1117-fold increase in its solubility due to the inclusion complex with chitosan conjugate. |
| first_indexed | 2024-03-10T08:06:05Z |
| format | Article |
| id | doaj.art-9fbb5de3853f474898688c71b941b83c |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T08:06:05Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-9fbb5de3853f474898688c71b941b83c2023-11-22T11:05:36ZengMDPI AGPolymers2073-43602021-08-011317293910.3390/polym13172939Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug CarriersYili Ding0Wutong Cui1Chamakura V. N. S. Vara Prasad2Bingyun Wang3Life Science Department, Foshan University, Foshan 528000, ChinaLife Science Department, Foshan University, Foshan 528000, ChinaDas Pharma, Turangi P.O., Kakinada 533016, IndiaLife Science Department, Foshan University, Foshan 528000, ChinaCholic acid and galactose or lactose dual conjugated chitosan derivatives were designed and synthesized as potential anti liver cancer drug carriers, their structures were characterized through proton NMR spectra, elemental analysis, size distribution, zeta potential, and scanning electron microscope image studies. The ability of the dual conjugates to enhance the aqueous solubility of the cancer drug sorafenib was evaluated. The entrapment efficiency (EE%) and drug content (DC%) of sorafenib in the inclusion complexes were measured. The chitosan dual conjugate with cholic acid and galactose was found to be best in enhancing the aqueous solubility of sorafenib. The solubility of sorafenib in water has increased from 1.7 µg/mL to 1900 µg/mL which is equal to 1117-fold increase in its solubility due to the inclusion complex with chitosan conjugate.https://www.mdpi.com/2073-4360/13/17/2939lactosegalactosecholic aciddual conjugated chitosan derivativessorafenibsolubility |
| spellingShingle | Yili Ding Wutong Cui Chamakura V. N. S. Vara Prasad Bingyun Wang Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers Polymers lactose galactose cholic acid dual conjugated chitosan derivatives sorafenib solubility |
| title | Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers |
| title_full | Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers |
| title_fullStr | Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers |
| title_full_unstemmed | Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers |
| title_short | Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers |
| title_sort | design and synthesis of lactose galactose and cholic acid related dual conjugated chitosan derivatives as potential anti liver cancer drug carriers |
| topic | lactose galactose cholic acid dual conjugated chitosan derivatives sorafenib solubility |
| url | https://www.mdpi.com/2073-4360/13/17/2939 |
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