Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction

Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction

Background: Although several studies suggest that heparins prevent arrhythmias caused by acute myocardial infarction (AMI), the molecular mechanisms involved remain unclear. To investigate the involvement of pharmacological modulation of adenosine (ADO) signaling in cardiac cells by a low-molecular...

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Main Authors: Carlos Eduardo Braga Filho, Adriano Henrique Pereira Barbosa, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Marcelo Pires-Oliveira, Rui Manuel dos Santos Póvoa, Tânia Carmen Penãranda Govato, Hézio Jadir Fernandes Júnior, Rafael Guzella de Carvalho, Bráulio Luna-Filho, Fernando Sabia Tallo, Erisvaldo Amarante de Araújo, José Gustavo Padrão Tavares, Ricardo Mario Arida, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
low-molecular weight heparin
enoxaparin
cardiac ischemia/reperfusion
cardiac arrhythmias
purinergic signaling
Online Access:https://www.mdpi.com/2308-3425/10/3/103

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