Telomere dynamics in adult hematological malignancies
Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and end-to-end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often abl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2019-02-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201901-0001_telomere_dynamics_in_adult_hematological_malignancies.php |
| _version_ | 1819158761436086272 |
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| author | Helena Olbertova Karla Plevova Kamila Stranska Sarka Pospisilova |
| author_facet | Helena Olbertova Karla Plevova Kamila Stranska Sarka Pospisilova |
| author_sort | Helena Olbertova |
| collection | DOAJ |
| description | Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and end-to-end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed. |
| first_indexed | 2024-12-22T16:29:48Z |
| format | Article |
| id | doaj.art-9fbc4b49a50b4c7f99290c7f5ef371fb |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-22T16:29:48Z |
| publishDate | 2019-02-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-9fbc4b49a50b4c7f99290c7f5ef371fb2022-12-21T18:20:05ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212019-02-0116311710.5507/bp.2018.084bio-201901-0001Telomere dynamics in adult hematological malignanciesHelena Olbertova0Karla Plevova1Kamila Stranska2Sarka Pospisilova3Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech RepublicCenter of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech RepublicCenter of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech RepublicCenter of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech RepublicTelomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and end-to-end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed.https://biomed.papers.upol.cz/artkey/bio-201901-0001_telomere_dynamics_in_adult_hematological_malignancies.phptelomeretelomeraseleukemialymphomahematooncologyaging |
| spellingShingle | Helena Olbertova Karla Plevova Kamila Stranska Sarka Pospisilova Telomere dynamics in adult hematological malignancies Biomedical Papers telomere telomerase leukemia lymphoma hematooncology aging |
| title | Telomere dynamics in adult hematological malignancies |
| title_full | Telomere dynamics in adult hematological malignancies |
| title_fullStr | Telomere dynamics in adult hematological malignancies |
| title_full_unstemmed | Telomere dynamics in adult hematological malignancies |
| title_short | Telomere dynamics in adult hematological malignancies |
| title_sort | telomere dynamics in adult hematological malignancies |
| topic | telomere telomerase leukemia lymphoma hematooncology aging |
| url | https://biomed.papers.upol.cz/artkey/bio-201901-0001_telomere_dynamics_in_adult_hematological_malignancies.php |
| work_keys_str_mv | AT helenaolbertova telomeredynamicsinadulthematologicalmalignancies AT karlaplevova telomeredynamicsinadulthematologicalmalignancies AT kamilastranska telomeredynamicsinadulthematologicalmalignancies AT sarkapospisilova telomeredynamicsinadulthematologicalmalignancies |