Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice
As a result of physical exercise, muscle releases multiple exerkines, such as “irisin”, which is thought to induce pro-cognitive and antidepressant effects. We recently demonstrated in young healthy mice the mitigation of depressive behaviors induced by consecutive 5 day irisin administration. To un...
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9111 |
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| author | Manuela Dicarlo Patrizia Pignataro Roberta Zerlotin Clelia Suriano Chiara Zecca Maria Teresa Dell’Abate Giuseppina Storlino Angela Oranger Lorenzo Sanesi Giorgio Mori Maria Grano Graziana Colaianni Silvia Colucci |
| author_facet | Manuela Dicarlo Patrizia Pignataro Roberta Zerlotin Clelia Suriano Chiara Zecca Maria Teresa Dell’Abate Giuseppina Storlino Angela Oranger Lorenzo Sanesi Giorgio Mori Maria Grano Graziana Colaianni Silvia Colucci |
| author_sort | Manuela Dicarlo |
| collection | DOAJ |
| description | As a result of physical exercise, muscle releases multiple exerkines, such as “irisin”, which is thought to induce pro-cognitive and antidepressant effects. We recently demonstrated in young healthy mice the mitigation of depressive behaviors induced by consecutive 5 day irisin administration. To understand which molecular mechanisms might be involved in such effect, we here studied, in a group of mice previously submitted to a behavioral test of depression, the gene expression of neurotrophins and cytokines in the hippocampus and prefrontal cortex (PFC), two brain areas frequently investigated in the depression pathogenesis. We found significantly increased mRNA levels of nerve growth factor (NGF) and fibroblast growth factor 2 (FGF-2) in the hippocampus and brain-derived growth factor (BDNF) in the PFC. We did not detect a difference in the mRNA levels of interleukin 6 (IL-6) and IL-1β in both brain regions. Except for BDNF in the PFC, two-way ANOVA analysis did not reveal sex differences in the expression of the tested genes. Overall, our data evidenced a site-specific cerebral modulation of neurotrophins induced by irisin treatment in the hippocampus and the PFC, contributing to the search for new antidepressant treatments targeted at single depressive events with short-term protocols. |
| first_indexed | 2024-03-11T03:06:50Z |
| format | Article |
| id | doaj.art-9fbcbe58172446ed8fe80bcce29b9927 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:06:50Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9fbcbe58172446ed8fe80bcce29b99272023-11-18T07:54:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411911110.3390/ijms24119111Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young MiceManuela Dicarlo0Patrizia Pignataro1Roberta Zerlotin2Clelia Suriano3Chiara Zecca4Maria Teresa Dell’Abate5Giuseppina Storlino6Angela Oranger7Lorenzo Sanesi8Giorgio Mori9Maria Grano10Graziana Colaianni11Silvia Colucci12Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyCenter for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari at “Pia Fondazione Card G. Panico” Hospital, Via San Pio X, 4, 73039 Tricase, ItalyCenter for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari at “Pia Fondazione Card G. Panico” Hospital, Via San Pio X, 4, 73039 Tricase, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Translational Biomedicine and Neuroscience, University of Bari, 70124 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Translational Biomedicine and Neuroscience, University of Bari, 70124 Bari, ItalyAs a result of physical exercise, muscle releases multiple exerkines, such as “irisin”, which is thought to induce pro-cognitive and antidepressant effects. We recently demonstrated in young healthy mice the mitigation of depressive behaviors induced by consecutive 5 day irisin administration. To understand which molecular mechanisms might be involved in such effect, we here studied, in a group of mice previously submitted to a behavioral test of depression, the gene expression of neurotrophins and cytokines in the hippocampus and prefrontal cortex (PFC), two brain areas frequently investigated in the depression pathogenesis. We found significantly increased mRNA levels of nerve growth factor (NGF) and fibroblast growth factor 2 (FGF-2) in the hippocampus and brain-derived growth factor (BDNF) in the PFC. We did not detect a difference in the mRNA levels of interleukin 6 (IL-6) and IL-1β in both brain regions. Except for BDNF in the PFC, two-way ANOVA analysis did not reveal sex differences in the expression of the tested genes. Overall, our data evidenced a site-specific cerebral modulation of neurotrophins induced by irisin treatment in the hippocampus and the PFC, contributing to the search for new antidepressant treatments targeted at single depressive events with short-term protocols.https://www.mdpi.com/1422-0067/24/11/9111depressionantidepressantirisinfibronectin type III domain containing 5physical exerciseBDNF |
| spellingShingle | Manuela Dicarlo Patrizia Pignataro Roberta Zerlotin Clelia Suriano Chiara Zecca Maria Teresa Dell’Abate Giuseppina Storlino Angela Oranger Lorenzo Sanesi Giorgio Mori Maria Grano Graziana Colaianni Silvia Colucci Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice International Journal of Molecular Sciences depression antidepressant irisin fibronectin type III domain containing 5 physical exercise BDNF |
| title | Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice |
| title_full | Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice |
| title_fullStr | Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice |
| title_full_unstemmed | Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice |
| title_short | Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice |
| title_sort | short term irisin treatment enhanced neurotrophin expression differently in the hippocampus and the prefrontal cortex of young mice |
| topic | depression antidepressant irisin fibronectin type III domain containing 5 physical exercise BDNF |
| url | https://www.mdpi.com/1422-0067/24/11/9111 |
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