Recurrent implantation failure: A comprehensive summary from etiology to treatment
Implantation is the first step in human reproduction. Successful implantation depends on the crosstalk between embryo and endometrium. Recurrent implantation failure (RIF) is a clinical phenomenon characterized by a lack of implantation after the transfer of several embryos and disturbs approximatel...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1061766/full |
| _version_ | 1797960755610386432 |
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| author | Junying Ma Junying Ma Junying Ma Wenyan Gao Da Li Da Li Da Li |
| author_facet | Junying Ma Junying Ma Junying Ma Wenyan Gao Da Li Da Li Da Li |
| author_sort | Junying Ma |
| collection | DOAJ |
| description | Implantation is the first step in human reproduction. Successful implantation depends on the crosstalk between embryo and endometrium. Recurrent implantation failure (RIF) is a clinical phenomenon characterized by a lack of implantation after the transfer of several embryos and disturbs approximately 10% couples undergoing in vitro fertilization and embryo transfer. Despite increasing literature on RIF, there is still no widely accepted definition or standard protocol for the diagnosis and treatment of RIF. Progress in predicting and preventing RIF has been hampered by a lack of widely accepted definitions. Most couples with RIF can become pregnant after clinical intervention. The prognosis for couples with RIF is related to maternal age. RIF can be caused by immunology, thrombophilias, endometrial receptivity, microbiome, anatomical abnormalities, male factors, and embryo aneuploidy. It is important to determine the most possible etiologies, and individualized treatment aimed at the primary cause seems to be an effective method for increasing the implantation rate. Couples with RIF require psychological support and appropriate clinical intervention. Further studies are required to evaluate diagnostic method and he effectiveness of each therapy, and guide clinical treatment. |
| first_indexed | 2024-04-11T00:49:14Z |
| format | Article |
| id | doaj.art-9fbd38f4885b468984f50f6fc676fde5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T00:49:14Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9fbd38f4885b468984f50f6fc676fde52023-01-05T11:56:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10617661061766Recurrent implantation failure: A comprehensive summary from etiology to treatmentJunying Ma0Junying Ma1Junying Ma2Wenyan Gao3Da Li4Da Li5Da Li6Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Reproductive and Genetic Medicine, China Medical University, National Health Commission, Shenyang, ChinaShengjing Hospital of China Medical University, Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, Shenyang, ChinaDepartment of Obstetrics, the First Affiliated Hospital of China Medical University, Shenyang, ChinaCenter of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Reproductive and Genetic Medicine, China Medical University, National Health Commission, Shenyang, ChinaShengjing Hospital of China Medical University, Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, Shenyang, ChinaImplantation is the first step in human reproduction. Successful implantation depends on the crosstalk between embryo and endometrium. Recurrent implantation failure (RIF) is a clinical phenomenon characterized by a lack of implantation after the transfer of several embryos and disturbs approximately 10% couples undergoing in vitro fertilization and embryo transfer. Despite increasing literature on RIF, there is still no widely accepted definition or standard protocol for the diagnosis and treatment of RIF. Progress in predicting and preventing RIF has been hampered by a lack of widely accepted definitions. Most couples with RIF can become pregnant after clinical intervention. The prognosis for couples with RIF is related to maternal age. RIF can be caused by immunology, thrombophilias, endometrial receptivity, microbiome, anatomical abnormalities, male factors, and embryo aneuploidy. It is important to determine the most possible etiologies, and individualized treatment aimed at the primary cause seems to be an effective method for increasing the implantation rate. Couples with RIF require psychological support and appropriate clinical intervention. Further studies are required to evaluate diagnostic method and he effectiveness of each therapy, and guide clinical treatment.https://www.frontiersin.org/articles/10.3389/fendo.2022.1061766/fullrecurrent implantation failureimmunologythrombophiliasendometrial receptivitymicrobiomeanatomical abnormalities |
| spellingShingle | Junying Ma Junying Ma Junying Ma Wenyan Gao Da Li Da Li Da Li Recurrent implantation failure: A comprehensive summary from etiology to treatment Frontiers in Endocrinology recurrent implantation failure immunology thrombophilias endometrial receptivity microbiome anatomical abnormalities |
| title | Recurrent implantation failure: A comprehensive summary from etiology to treatment |
| title_full | Recurrent implantation failure: A comprehensive summary from etiology to treatment |
| title_fullStr | Recurrent implantation failure: A comprehensive summary from etiology to treatment |
| title_full_unstemmed | Recurrent implantation failure: A comprehensive summary from etiology to treatment |
| title_short | Recurrent implantation failure: A comprehensive summary from etiology to treatment |
| title_sort | recurrent implantation failure a comprehensive summary from etiology to treatment |
| topic | recurrent implantation failure immunology thrombophilias endometrial receptivity microbiome anatomical abnormalities |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1061766/full |
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