Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes
Abstract Background As the nonalcoholic fatty liver disease (NAFLD) epidemic matures, understanding how metabolic changes in NAFLD development vary over the age distribution is important to guide precise prevention. We aimed to clarify metabolic trends in age-specific NAFLD incidence. Methods We con...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-022-00930-w |
| _version_ | 1811315296305152000 |
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| author | Yansong Lin Xiongcai Feng Xu Cao Rong Miao Yanhong Sun Rui Li Junzhao Ye Bihui Zhong |
| author_facet | Yansong Lin Xiongcai Feng Xu Cao Rong Miao Yanhong Sun Rui Li Junzhao Ye Bihui Zhong |
| author_sort | Yansong Lin |
| collection | DOAJ |
| description | Abstract Background As the nonalcoholic fatty liver disease (NAFLD) epidemic matures, understanding how metabolic changes in NAFLD development vary over the age distribution is important to guide precise prevention. We aimed to clarify metabolic trends in age-specific NAFLD incidence. Methods We conducted a 4-year longitudinal retrospective cohort study enrolling 10,240 consecutive healthy individuals who received annual physical examination during 2012–2019. Baseline and dynamic changes in metabolism and hepatic steatosis determined with ultrasound were collected and analyzed stratified by age into the following groups: 20–34, 35–49, 50–64, and over 65 years. Results Overall, 1701 incident NAFLD participants (16.6%) were identified. Adjusted Cox regression analysis showed that the baseline and increased body mass index were the main risk factors for NAFLD in people ≤ 65 years old. Baseline high-density lipoprotein (HR = 0.56; 95% CI 0.39–0.78) was a protective factor for newly onset NAFLD in the 50-to-64-year-old group, while baseline SBP (HR = 1.03; 95% CI 1.01–1.05), baseline uric acid (HR = 1.04; 95% CI 1.01–1.07), triglyceride increase (HR = 4.76; 95% CI 3.69–6.14), fasting blood glucose increase (HR = 1.32; 95% CI 1.06–1.65) were independently associated with incident NAFLD in over-65-year-old group. Conclusions NAFLD incidence attributable to potentially metabolic risk factors varied substantially across age groups in a cohort of Chinese people. The adoption of age targeted metabolic prevention strategies might reduce the burden of NAFLD. |
| first_indexed | 2024-04-13T11:27:44Z |
| format | Article |
| id | doaj.art-9fbe8189e3234cd0aa0d7698156b4be6 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-13T11:27:44Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-9fbe8189e3234cd0aa0d7698156b4be62022-12-22T02:48:39ZengBMCDiabetology & Metabolic Syndrome1758-59962022-11-0114111210.1186/s13098-022-00930-wAge patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changesYansong Lin0Xiongcai Feng1Xu Cao2Rong Miao3Yanhong Sun4Rui Li5Junzhao Ye6Bihui Zhong7Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen UniversityPhysical Examination Center, The East Division of the First Affiliated Hospital, Sun Yat-Sen UniversityPhysical Examination Center, The East Division of the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen UniversityAbstract Background As the nonalcoholic fatty liver disease (NAFLD) epidemic matures, understanding how metabolic changes in NAFLD development vary over the age distribution is important to guide precise prevention. We aimed to clarify metabolic trends in age-specific NAFLD incidence. Methods We conducted a 4-year longitudinal retrospective cohort study enrolling 10,240 consecutive healthy individuals who received annual physical examination during 2012–2019. Baseline and dynamic changes in metabolism and hepatic steatosis determined with ultrasound were collected and analyzed stratified by age into the following groups: 20–34, 35–49, 50–64, and over 65 years. Results Overall, 1701 incident NAFLD participants (16.6%) were identified. Adjusted Cox regression analysis showed that the baseline and increased body mass index were the main risk factors for NAFLD in people ≤ 65 years old. Baseline high-density lipoprotein (HR = 0.56; 95% CI 0.39–0.78) was a protective factor for newly onset NAFLD in the 50-to-64-year-old group, while baseline SBP (HR = 1.03; 95% CI 1.01–1.05), baseline uric acid (HR = 1.04; 95% CI 1.01–1.07), triglyceride increase (HR = 4.76; 95% CI 3.69–6.14), fasting blood glucose increase (HR = 1.32; 95% CI 1.06–1.65) were independently associated with incident NAFLD in over-65-year-old group. Conclusions NAFLD incidence attributable to potentially metabolic risk factors varied substantially across age groups in a cohort of Chinese people. The adoption of age targeted metabolic prevention strategies might reduce the burden of NAFLD.https://doi.org/10.1186/s13098-022-00930-wNonalcoholic fatty liver diseaseIncidence rateAgingRisk factorsMetabolic disorder |
| spellingShingle | Yansong Lin Xiongcai Feng Xu Cao Rong Miao Yanhong Sun Rui Li Junzhao Ye Bihui Zhong Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes Diabetology & Metabolic Syndrome Nonalcoholic fatty liver disease Incidence rate Aging Risk factors Metabolic disorder |
| title | Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes |
| title_full | Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes |
| title_fullStr | Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes |
| title_full_unstemmed | Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes |
| title_short | Age patterns of nonalcoholic fatty liver disease incidence: heterogeneous associations with metabolic changes |
| title_sort | age patterns of nonalcoholic fatty liver disease incidence heterogeneous associations with metabolic changes |
| topic | Nonalcoholic fatty liver disease Incidence rate Aging Risk factors Metabolic disorder |
| url | https://doi.org/10.1186/s13098-022-00930-w |
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